Title:
CHIMERIC ANTIGEN RECEPTOR MODIFIED BY UBIQUITIN COUPLING AND IMMUNE CELL
Document Type and Number:
WIPO Patent Application WO/2023/005219
Kind Code:
A1
Abstract:
Provided are a chimeric antigen receptor modified by ubiquitin coupling and an immune cell. The ubiquitin is coupled to a C-terminus of the chimeric antigen receptor, and is suitable for a variety of current CAR-T cell production technologies, and particularly suitable for CAR-T therapeutic products developed against solid tumor targets.
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Inventors:
WANG HAOPENG (CN)
QIU SHIZHEN (CN)
LI WENTAO (CN)
WANG KUN (CN)
CHEN JIAN (CN)
SONG XIANMIN (CN)
QIU SHIZHEN (CN)
LI WENTAO (CN)
WANG KUN (CN)
CHEN JIAN (CN)
SONG XIANMIN (CN)
Application Number:
PCT/CN2022/080608
Publication Date:
February 02, 2023
Filing Date:
March 14, 2022
Export Citation:
Assignee:
UNIV SHANGHAI TECH (CN)
International Classes:
C07K14/705; A61K39/395; A61P35/00; C07K14/725; C07K16/28; C07K19/00; C12N5/10; C12N15/09; C12N15/62; C12N15/85
Foreign References:
| US20190010220A1 | 2019-01-10 | |||
| US20120283408A1 | 2012-11-08 | |||
| US20130123199A1 | 2013-05-16 | |||
| CN110055281A | 2019-07-26 | |||
| CN111686128A | 2020-09-22 | |||
| CN109021116A | 2018-12-18 |
Other References:
KUNII NAOKI, ZHAO YANGBING, JIANG SHUGUANG, LIU XIAOJUN, SCHOLLER JOHN, BALAGOPALAN LAKSHMI, SAMELSON LAWRENCE E., MILONE MICHAEL : "Enhanced Function of Redirected Human T Cells Expressing Linker for Activation of T Cells That Is Resistant to Ubiquitylation", HUMAN GENE THERAPY, MARY ANN LIEBERT, INC. PUBLISHERS, GB, vol. 24, no. 1, 1 January 2013 (2013-01-01), GB , pages 27 - 37, XP055830818, ISSN: 1043-0342, DOI: 10.1089/hum.2012.130
Attorney, Agent or Firm:
J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (CN)
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