Title:
CHIMERIC ANTIGEN RECEPTOR, NKG2D CAR-NK CELL EXPRESSING CHIMERIC ANTIGEN RECEPTOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/154391
Kind Code:
A1
Abstract:
Provided are a chimeric antigen receptor, a NKG2D CAR-NK cell expressing the chimeric antigen receptor, a preparation method therefor and the use thereof. The chimeric antigen receptor comprises an antigen binding domain, a transmembrane domain and a co-stimulatory signaling region. The antigen binding domain can specifically bind to a tumor-specific antigen NKG2D ligand, and activate NK cells through the transmembrane domain and the co-stimulatory signaling region. The CAR-NK cell provided by the present invention uses the NKG2D ligand as a target antigen, and specifically kills tumor cells using NKG2D CAR-NK cells. The CAR-NK cell can be used as a medicament for treating tumor diseases and can be used for treating the tumor in which the ligand of NKG2D molecules highly expresses, providing a new method for the prevention and treatment of tumors.
Inventors:
LI HUASHUN (CN)
HAN KUNKUN (CN)
HAN JUNFENG (CN)
HAN KUNKUN (CN)
HAN JUNFENG (CN)
Application Number:
PCT/CN2019/074683
Publication Date:
August 15, 2019
Filing Date:
February 03, 2019
Export Citation:
Assignee:
LI HUASHUN (CN)
International Classes:
C07K19/00; A61K35/17; A61P35/00; C12N5/10; C12N15/63
Domestic Patent References:
| WO2016201304A1 | 2016-12-15 |
Foreign References:
| US20180028632A1 | 2018-02-01 | |||
| CN107428843A | 2017-12-01 |
Attorney, Agent or Firm:
BEIJING BRIGHT IP AGENCY CO., LTD. (CN)
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