Title:
CHIMERIC ANTIGEN RECEPTOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/195749
Kind Code:
A1
Abstract:
Provided are a novel CAR, CAR T-cells, and the like which are effective in treating diseases such as cancer. This chimeric antigen receptor is selected from the group consisting of chimeric antigen receptors A-F. The CAR T-cells express said chimeric antigen receptor.
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Inventors:
NAKAGAWA SHINSAKU (JP)
OKADA NAOKI (JP)
KAMIGAKI TAKASHI (JP)
SASAWATARI SHIGEMI (JP)
OKADA NAOKI (JP)
KAMIGAKI TAKASHI (JP)
SASAWATARI SHIGEMI (JP)
Application Number:
PCT/JP2017/017456
Publication Date:
November 16, 2017
Filing Date:
May 09, 2017
Export Citation:
Assignee:
UNIV OSAKA (JP)
MEDINET CO LTD (JP)
MEDINET CO LTD (JP)
International Classes:
C12N15/09; A61K35/17; A61P35/00; C07K19/00; C12N5/16; C07K16/00
Foreign References:
| JP2013506419A | 2013-02-28 |
Other References:
KANAGAWA, N. ET AL.: "Tumor vessel-injuring ability improves antitumor effect of cytotoxic T lymphocytes in adoptive immunotherapy", CANCER GENE THERAPY, vol. 20, no. 1, January 2013 (2013-01-01), pages 57 - 64, XP055599900, DOI: 10.1038/cgt.2012.85
CHINNASAMY, D. ET AL.: "Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 120, no. 11, 2010, pages 3953 - 3968, XP002605940, ISSN: 1558-8238
KANAGAWA, N. ET AL.: "Tumor-targeting CTL expressing a single-chain Fv specific for VEGFR2", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 394, no. 1, 2010, pages 54 - 58, XP055599905, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2010.02.085
YOSHIKAWA, M. ET AL.: "Robo4 is and effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell -internalizing antibody", BLOOD, vol. 121, no. 14, 2013, pages 2804 - 2813, XP055077522, ISSN: 1528-0020, DOI: doi:10.1182/blood-2012-12-468363
INOO, K. ET AL.: "Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA- EP for clinical research", MOLECULAR THERAPY - ONCOLYTICS, vol. 3, November 2016 (2016-11-01), pages 16024, XP055509956, ISSN: 2372-7705, DOI: doi:10.1038/mto.2016.24
CAWKWELL, L. ET AL.: "Engineering T cells for cancer therapy by expressing a chimeric antigen receptor (CAR) targeting the tumour endothelial marker ROB04", EUR. J. IMMUNOL., vol. 46, no. 1, August 2016 (2016-08-01), pages 124 - 125, ISSN: 1521-4141
NAKAZAWA, YOZO: "Gene-modified t-cell Therapy Using Chimeric Antigen Receptor", THE SHINSHU MEDICAL JOURNAL, vol. 61, no. 4, 2013, pages 197 - 203, XP055516593
CHINNASAMY, D. ET AL.: "Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 120, no. 11, 2010, pages 3953 - 3968, XP002605940, ISSN: 1558-8238
KANAGAWA, N. ET AL.: "Tumor-targeting CTL expressing a single-chain Fv specific for VEGFR2", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 394, no. 1, 2010, pages 54 - 58, XP055599905, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2010.02.085
YOSHIKAWA, M. ET AL.: "Robo4 is and effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell -internalizing antibody", BLOOD, vol. 121, no. 14, 2013, pages 2804 - 2813, XP055077522, ISSN: 1528-0020, DOI: doi:10.1182/blood-2012-12-468363
INOO, K. ET AL.: "Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA- EP for clinical research", MOLECULAR THERAPY - ONCOLYTICS, vol. 3, November 2016 (2016-11-01), pages 16024, XP055509956, ISSN: 2372-7705, DOI: doi:10.1038/mto.2016.24
CAWKWELL, L. ET AL.: "Engineering T cells for cancer therapy by expressing a chimeric antigen receptor (CAR) targeting the tumour endothelial marker ROB04", EUR. J. IMMUNOL., vol. 46, no. 1, August 2016 (2016-08-01), pages 124 - 125, ISSN: 1521-4141
NAKAZAWA, YOZO: "Gene-modified t-cell Therapy Using Chimeric Antigen Receptor", THE SHINSHU MEDICAL JOURNAL, vol. 61, no. 4, 2013, pages 197 - 203, XP055516593
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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