Title:
CHIMERIC ANTIGEN RECEPTORS TARGETING CANCER
Document Type and Number:
WIPO Patent Application WO/2017/172981
Kind Code:
A3
Abstract:
Provided herein is a composition comprising, a cell, comprising nucleic acids encoding a chimeric antigen receptor (CAR) and one or more of signaling proteins selected from K13-vFLIP, MC159-vFLIP, cFLIP-L, cFLIP-p22, HTLV1-Tax and HTLV2-Tax, wherein the CAR comprises an a) extracellular antigen specific domain, b) a transmembrane domain and c) an intracellular signaling domain comprising an immunoreceptor tyrosine-based activation motif (ITAM); wherein c) is located at the C-terminus of the chimeric receptor. In some embodiments, the CAR further comprises one or more co-stimulatory domains. Also provided herein are methods for treating diseases using the compositions described herein.
Inventors:
CHAUDHARY PREET M (US)
Application Number:
PCT/US2017/024843
Publication Date:
November 09, 2017
Filing Date:
March 29, 2017
Export Citation:
Assignee:
UNIV SOUTHERN CALIFORNIA (US)
International Classes:
A61K39/395; C07K14/705; C07K14/725; C07K16/28
Domestic Patent References:
| WO2015150526A2 | 2015-10-08 | |||
| WO2017103596A1 | 2017-06-22 | |||
| WO2016210447A1 | 2016-12-29 |
Foreign References:
| US20130017575A1 | 2013-01-17 | |||
| US20130143791A1 | 2013-06-06 | |||
| US20060222588A1 | 2006-10-05 | |||
| US20140271635A1 | 2014-09-18 |
Other References:
MATTA, H ET AL.: "A Nuclear Role for Kaposi's Sarcoma-Associated Herpesvirus-Encoded K13 Protein in Gene Regulation", ONCOGENE, vol. 27, no. 39, 12 May 2008 (2008-05-12), pages 5243 - 5253, XP055439387
POWNALL, ME ET AL.: "An Inducible System for the Study of FGF Signalling in Early Amphibian Development", DEVELOPMENT BIOLOGY, vol. 256, no. 1, 1 April 2013 (2013-04-01), pages 89 - 99, XP055439389
MAUDE, SL ET AL.: "Chimeric antigen receptor T- cell therapy for ALL", HEMATOLOGY, vol. 2014, no. 1, 18 November 2014 (2014-11-18), pages 559 - 564, XP055439390
WU, Z ET AL.: "TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD 110+ Tumor- Initiating Cells", CELL STEM CELL, vol. 17, no. 1, 2 July 2015 (2015-07-02), pages 47 - 59, XP055439391
TETTAMANTI, S ET AL.: "CD 123 AML Targeting by Chimeric Antigen Receptors", ONCOIMMUNOLOGY, vol. 3, 1 May 2014 (2014-05-01), pages e28835 - 1-5, XP055150827
HOSING, C ET AL.: "CARs in Chronic Lymphocytic Leukemia - Ready to Drive", CURRENT HEMATOLOGY MALIGNANCY REPORTS, vol. 8, no. 1, March 2013 (2013-03-01), pages 1 - 17, XP055163475
POWNALL, ME ET AL.: "An Inducible System for the Study of FGF Signalling in Early Amphibian Development", DEVELOPMENT BIOLOGY, vol. 256, no. 1, 1 April 2013 (2013-04-01), pages 89 - 99, XP055439389
MAUDE, SL ET AL.: "Chimeric antigen receptor T- cell therapy for ALL", HEMATOLOGY, vol. 2014, no. 1, 18 November 2014 (2014-11-18), pages 559 - 564, XP055439390
WU, Z ET AL.: "TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD 110+ Tumor- Initiating Cells", CELL STEM CELL, vol. 17, no. 1, 2 July 2015 (2015-07-02), pages 47 - 59, XP055439391
TETTAMANTI, S ET AL.: "CD 123 AML Targeting by Chimeric Antigen Receptors", ONCOIMMUNOLOGY, vol. 3, 1 May 2014 (2014-05-01), pages e28835 - 1-5, XP055150827
HOSING, C ET AL.: "CARs in Chronic Lymphocytic Leukemia - Ready to Drive", CURRENT HEMATOLOGY MALIGNANCY REPORTS, vol. 8, no. 1, March 2013 (2013-03-01), pages 1 - 17, XP055163475
Attorney, Agent or Firm:
VAKHARIA-RAO, Hema et al. (US)
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