Title:
CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/027795
Kind Code:
A1
Abstract:
Provide is a chimeric antigen receptor. The chimeric antigen receptor comprises an extracellular domain including a heavy chain variable region, a light chain variable region of a single chain antibody fragment and CD8 hinge region; a transmembrane domain including an immune co-stimulator transmembrane domain; and an intracellular domain including an immune co-stimulator intracellular segment and CD3ζ chain. The chimeric antigen receptor can specifically recognize the tumor cells expressing the specific antigen and achieve the specific killing effect against the tumor cells expressing the high specific antigen.
Inventors:
CHEN CHAO (CN)
DONG JUNJI (CN)
YU TINGTING (CN)
ZENG YI (CN)
XU LE (CN)
WANG XUFANG (CN)
LI ZHIGUANG (CN)
LI SHAOYAN (CN)
YE QUNRUI (CN)
CHEN XIAOFENG (CN)
LI WENJIA (CN)
DONG JUNJI (CN)
YU TINGTING (CN)
ZENG YI (CN)
XU LE (CN)
WANG XUFANG (CN)
LI ZHIGUANG (CN)
LI SHAOYAN (CN)
YE QUNRUI (CN)
CHEN XIAOFENG (CN)
LI WENJIA (CN)
Application Number:
PCT/CN2020/108327
Publication Date:
February 18, 2021
Filing Date:
August 11, 2020
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07K19/00; A61K39/00; C07K16/28; C12N5/10; C12N15/85
Domestic Patent References:
| WO2019061012A1 | 2019-04-04 | |||
| WO2018064205A1 | 2018-04-05 |
Foreign References:
| CN111253487A | 2020-06-09 | |||
| CN109485733A | 2019-03-19 | |||
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| CN109734813A | 2019-05-10 | |||
| CN107298715A | 2017-10-27 | |||
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Other References:
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See also references of EP 4013798A4
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBORPRESS
REITER ET AL., PROTEIN ENGINEERING, vol. 7, 1994, pages 697 - 704
GRAHAM ET AL., VIROLOGY, vol. 52, 1973, pages 456 - 467
DAVIS ET AL.: "Basic Methods in Molecular Biology", 1986, ELSEVIER, pages: 622 - 630
CHU ET AL., GENE, vol. 13, 1981, pages 97
CAPECCHI, CELL, vol. 22, 1980, pages 479 - 488
SHIGEKAWA ET AL., BIOTECHNIQUES, vol. 6, 1988, pages 682 - 690
FEIGNER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 84, 1987, pages 7413 - 7417
KLEIN ET AL., NATURE, vol. 327, 1987, pages 70 - 73
CAROLINE J.: "Suicide Gene Therapy: Methods and Reviews", 2004, HUMANA PRESS, article "Cancer Research UK Centre for Cancer Therapeutics at the Institute of Cancer Research"
HUDECZ, F., METHODS MOL. BIOL., vol. 298, 2005, pages 209 - 223
KIRIN ET AL., INORG CHEM., vol. 44, no. 15, 2005, pages 5405 - 5415
"Remington: The Science and Practice of Pharmacy", 1 May 2005, LIPPINCOTT WILLIAMS & WILKINS
"Pharmaceutics and Pharmacy Practice", 1982, J.B. LIPPINCOTT COMPANY, pages: 238 - 250
SZOKA ET AL., ANN. REV. BIOPHYS. BIOENG., vol. 9, 1980, pages 467
WADWA ET AL., J. DRUG TARGETING, vol. 3, 1995, pages 111
ZHAO ET AL., J. IMMUNOL, vol. 174, 2005, pages 4415 - 4423
See also references of EP 4013798A4
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