Title:
CHIMERIC BROAD-SPECTRUM ONCOLYTIC ADENOVIRUS WITH MULTIPLE MECHANISMS SYNERGIZING WITH AND ENHANCING EFFICACY OF IMMUNOTHERAPY, AND APPLICATION THEREOF IN TUMOR TREATMENT
Document Type and Number:
WIPO Patent Application WO/2022/246646
Kind Code:
A1
Abstract:
Provided are a chimeric oncolytic adenovirus simultaneously expressing IL-12, IFN-γ, and CCL5, and an application thereof in tumor treatment. A capsid protein hexon of the oncolytic adenovirus is formed from chimerizing hexon sequences of the two serotype viruses Ad5 and Ad48, and a fiber protein is formed from chimerizing fiber sequences of the two serotype viruses Ad5 and Ad11. The chimeric oncolytic adenovirus can activate intrinsic anti-cancer activity of a variety of viral structural proteins, the ability to infect tumor cells is increased while also ensuring that the virus itself avoids interception from pre-existing neutralizing antibodies and adhesion and uptake of hepatocytes, and an effect of killing cancer cells is enhanced.
Inventors:
LI JIANG (CN)
SU YINGHAN (CN)
SU YINGHAN (CN)
Application Number:
PCT/CN2021/095796
Publication Date:
December 01, 2022
Filing Date:
May 25, 2021
Export Citation:
Assignee:
VONCOLYTIC THERAPEUTICS CO LTD (CN)
International Classes:
C12N7/01; A61K35/761; A61K38/19; A61K38/20; A61K38/21; A61K48/00; A61P35/00; A61P35/04; C12N15/19; C12N15/23; C12N15/24; C12N15/34; C12R1/93
Foreign References:
| CN111658670A | 2020-09-15 | |||
| CN110741080A | 2020-01-31 | |||
| CN101781636A | 2010-07-21 | |||
| CN1884556A | 2006-12-27 |
Other References:
LI XING; MAO QINWEN; WANG DONGYANG; XIA HAIBIN: "A novel Ad5/11 chimeric oncolytic adenovirus for improved glioma therapy", INTERNATIONAL JOURNAL OF ONCOLOGY, DEMETRIOS A. SPANDIDOS ED. & PUB, GR, vol. 41, no. 6, 1 December 2012 (2012-12-01), GR , pages 2159 - 2165, XP008161897, ISSN: 1019-6439, DOI: 10.3892/ijo.2012.1674
IMMUNITY, vol. 49, 2018, pages 1148 - 1161
CELL, vol. 172, 2018, pages 1022 - 1037
IMMUNITY, vol. 49, 2018, pages 1148 - 1161
CELL, vol. 172, 2018, pages 1022 - 1037
Attorney, Agent or Firm:
SHANGHAI ZHUOYANG INTELLECTUAL PROPERTY AGENT FIRM (CN)
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