Title:
CHIMERIC FCεRI α-CHAIN GENE, CHIMERIC FCεRI α-CHAIN PROTEIN, CELLS, ANALYSIS KIT AND ANALYSIS METHOD
Document Type and Number:
WIPO Patent Application WO/2022/186041
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a means for improving allergy test sensitivity. Provided is a chimeric FcεRI α-chain gene that contains a first base sequence encoding the extracellular domain of human FcεRI α-chain and a second base sequence encoding at least the cell transmembrane domain of a non-human animal FcεRI α-chain. Also provided are a chimeric FcεRI α-chain protein that is the expression product of the chimeric FcεRI α-chain gene, and non-human animal cells containing the chimeric FcεRI α-chain gene. Also provided are an analysis kit containing the cells and an analysis method using the cells.
Inventors:
NAKAMURA RYOSUKE (JP)
AKIYAMA HARUYO (JP)
TADOKORO SATOSHI (JP)
KUMASAKA KENICHI (JP)
AKIYAMA HARUYO (JP)
TADOKORO SATOSHI (JP)
KUMASAKA KENICHI (JP)
Application Number:
PCT/JP2022/007612
Publication Date:
September 09, 2022
Filing Date:
February 24, 2022
Export Citation:
Assignee:
KANAGAWA PREFECTURE (JP)
JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NAT INSTITUTE OF HEALTH SCIENCES (JP)
TEIKYO HEISEI UNIV (JP)
JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NAT INSTITUTE OF HEALTH SCIENCES (JP)
TEIKYO HEISEI UNIV (JP)
International Classes:
C12N15/62; C07K14/735; C07K19/00; C12N5/10; C12N15/12; C12N15/63; C12Q1/02
Foreign References:
| JP2011019467A | 2011-02-03 |
Other References:
MALLAMACIS MICHAEL A, CHIZZONITEF RICHARD, GRIFFINF MAUREEN, NETTLETON$ MIGNON, HAKIMIF JOHN, TSIENQ WEN-HUI, KOCHAN$ JAREMA P: "dentification of Sites on the Human FceRIcr Subunit Which Are Involved in Binding Human and Rat IgE*", THE JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 268, 15 October 1993 (1993-10-15), pages 22076 - 22083, XP055962989
Attorney, Agent or Firm:
WATANABE Kaoru (JP)
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