CHIMERIC COMPOUND FOR DEGRADING CYCLOPHILIN A, PREPARATION METHOD THEREFOR, AND USE THEREOF

WIPO Patent Application WO/2024/031963

A1

Disclosed are a chimeric compound for degrading cyclophilin A, a preparation method therefor, and use thereof. The structural formula of the chimeric compound is represented by formula I. The compound represented by formula I provided by the present invention can be used for preventing and/or treating CypA-mediated diseases, such as CypA-mediated inflammation, autoimmune diseases and/or tumors. The present invention further provides a pharmaceutical composition comprising the compound represented by formula I as an active ingredient and at least one pharmaceutically acceptable carrier, excipient and/or diluent. The compound represented by formula I provided by the present invention can target and degrade the CypA protein, and thus can be used for preparing a drug for treating inflammation, autoimmune diseases, tumors and other related diseases. The compound represented by formula I of the present invention has the function of significantly inhibiting virus-induced pneumonia, rheumatoid arthritis and lung cancer cell migration and infiltration.

SUN LEI (CN)
LIU WENJUN (CN)
YANG WENXIAN (CN)
LI HEQIAO (CN)
BAI XIAOYUAN (CN)

PCT/CN2023/078634

February 15, 2024

February 28, 2023

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INST MICROBIOLOGY CAS (CN)

C07K5/062; A61K38/05; A61P29/00; A61P35/00; A61P37/02; C07K1/02; C07K1/12

WO2021229237A1	2021-11-18
WO2021190603A1	2021-09-30

CN115028681A	2022-09-09
CN109952299A	2019-06-28
CN103261212A	2013-08-21
CN107417766A	2017-12-01
CN113230382A	2021-08-10

JEEKAI & PARTNERS (CN)

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