Title:
CHIMERIC DECOY
Document Type and Number:
WIPO Patent Application WO/2017/043639
Kind Code:
A1
Abstract:
Disclosed is a double-stranded oligonucleotide decoy which includes two types of transcription factor binding sites and yet is small in size. The double-stranded oligonucleotide decoy according to the present invention having binding affinity to two types of transcription factors includes a first binding site for a first transcription factor, and a second binding site for a second transcription factor. A first strand including a sense strand of the first binding site and a second strand including a sense strand of the second binding site hybridize to form a double strand, and the sense strand of the first binding site and the sense strand of the second binding site are at least partially hybridized.
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Inventors:
MORISHITA RYUICHI (JP)
MIYAKE TAKASHI (JP)
MIYAKE TETSUO (JP)
NAKAZAWA TAKAHIRO (JP)
SAKAGUCHI MAKOTO (JP)
INOUE SATOSHI (JP)
UEKI RYOJI (JP)
MIYAKE TAKASHI (JP)
MIYAKE TETSUO (JP)
NAKAZAWA TAKAHIRO (JP)
SAKAGUCHI MAKOTO (JP)
INOUE SATOSHI (JP)
UEKI RYOJI (JP)
Application Number:
PCT/JP2016/076659
Publication Date:
March 16, 2017
Filing Date:
September 09, 2016
Export Citation:
Assignee:
ANGES MG INC (JP)
GENEDESIGN INC (JP)
GENEDESIGN INC (JP)
International Classes:
C12N15/09
Domestic Patent References:
| WO2006043722A1 | 2006-04-27 |
Foreign References:
| JP2005523703A | 2005-08-11 | |||
| JP2010526541A | 2010-08-05 | |||
| JP2011032269A | 2011-02-17 | |||
| JP2014037358A | 2014-02-27 |
Other References:
RYUICHI MORISHITA: "Innovation of decoy toward to real drugs", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 238, no. 5, 30 July 2011 (2011-07-30), pages 529 - 535, XP009509719
TAKASHI MIYAKE ET AL.: "Kakusan Iyaku o Mochiita Ketsueki Shikkan ni Taisuru Bunshi Chiryoho", FOLIA PHARMACOL.JPN., vol. 129, 2007, pages 158 - 162, XP055518805
CLARK P.R. ET AL.: "Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect", NUCLEIC ACIDS RESEARCH, vol. 36, no. 4, 20 December 2007 (2007-12-20), pages 1081 - 1097, XP055000172, DOI: doi:10.1093/nar/gkm630
See also references of EP 3348637A4
TAKASHI MIYAKE ET AL.: "Kakusan Iyaku o Mochiita Ketsueki Shikkan ni Taisuru Bunshi Chiryoho", FOLIA PHARMACOL.JPN., vol. 129, 2007, pages 158 - 162, XP055518805
CLARK P.R. ET AL.: "Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect", NUCLEIC ACIDS RESEARCH, vol. 36, no. 4, 20 December 2007 (2007-12-20), pages 1081 - 1097, XP055000172, DOI: doi:10.1093/nar/gkm630
See also references of EP 3348637A4
Attorney, Agent or Firm:
TANIGAWA AND PARTNERS, PATENT FIRM (JP)
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