Title:
CHIMERIC MCP AND DAF PROTEINS WITH CELL SURFACE LOCHIMERIC MCP AND DAF PROTEINS WITH CELL SURFACE LOCALIZING DOMAIN CALIZING DOMAIN
Document Type and Number:
WIPO Patent Application WO1996034965
Kind Code:
A3
Abstract:
Chimeric proteins containing sequences from MCP and DAF and further containing peptide sequences capable of binding glycosaminoglycans. Nucleotide sequences encoding the chimeric proteins, expression vectors containing the nucleotide sequences, as well as transformed host cells capable of producing the chimeric proteins are claimed.
Inventors:
INNIS MICHAEL A
ZAROR ISABEL
CREASEY ABLA A
ZAROR ISABEL
CREASEY ABLA A
Application Number:
PCT/US1996/006301
Publication Date:
January 03, 1997
Filing Date:
May 03, 1996
Export Citation:
Assignee:
CHIRON CORP (US)
International Classes:
C07K14/705; C07K19/00; C12N15/09; A61K38/00; (IPC1-7): C12N15/62; C07K14/705; C07K19/00; C12N1/80; C12N5/00
Foreign References:
| EP0512733A2 | 1992-11-11 |
Other References:
IWATA K. ET AL.: "Expression of a hybrid complement regulatory protein, membrane cofactor protein decay accelerating factor on chinese hamster ovary", JOURNAL OF IMMUNOLOGY, vol. 152, 1994, BALTIMORE US, pages 3436 - 3444, XP002018035
FODOR W.L. ET AL.: "A novel bifunctional chimeric complement inhibitor that regulates C3 convertase and formation of the membrane attack complex", JOURNAL OF IMMUNOLOGY, vol. 155, no. 9, November 1995 (1995-11-01), BALTIMORE US, pages 4135 - 4138, XP000608498
LUBLIN D AND COYNE K.: "Phosphoplipid-anchored and transmembrane versions of either decay-accelerating factor or membrane cofactor protein show equal efficiency in protection from complement-mediated cell damage", J. EXP. MED., vol. 174, 1991, pages 35 - 44, XP000607610
FODOR W.L. ET AL.: "A novel bifunctional chimeric complement inhibitor that regulates C3 convertase and formation of the membrane attack complex", JOURNAL OF IMMUNOLOGY, vol. 155, no. 9, November 1995 (1995-11-01), BALTIMORE US, pages 4135 - 4138, XP000608498
LUBLIN D AND COYNE K.: "Phosphoplipid-anchored and transmembrane versions of either decay-accelerating factor or membrane cofactor protein show equal efficiency in protection from complement-mediated cell damage", J. EXP. MED., vol. 174, 1991, pages 35 - 44, XP000607610
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