Title:
CHIMERIC MUTANT STRAIN OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUSES
Document Type and Number:
WIPO Patent Application WO/2015/056850
Kind Code:
A1
Abstract:
The present invention relates to a chimeric mutant strain of porcine reproductive and respiratory syndrome (PRRS) viruses, which can be used as a vaccine. The chimeric virus mutant strain of the present invention has high stability and can obtain a high antibody titer against viruses of the same genotype. As in the present invention, a customized chimeric virus mutant strain for each farm can be prepared by substituting ORF5 of a single mutant strain with ORF5 of another mutant strain. Therefore, the present invention can be used to effectively prevent PRRS which is a disease of domestic pigs causing serious economic damage.
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Inventors:
LEE JOONG-BOK (KR)
LEE JUNG AH (KR)
LEE NAK HYUNG (KR)
KWON BYUNG JOON (US)
CHOI IN-SOO (KR)
SONG CHANG SEON (KR)
PARK SEUNG YONG (KR)
LEE SANG WON (KR)
LEE JUNG AH (KR)
LEE NAK HYUNG (KR)
KWON BYUNG JOON (US)
CHOI IN-SOO (KR)
SONG CHANG SEON (KR)
PARK SEUNG YONG (KR)
LEE SANG WON (KR)
Application Number:
PCT/KR2014/001700
Publication Date:
April 23, 2015
Filing Date:
February 28, 2014
Export Citation:
Assignee:
UNIV KONKUK IND COOP CORP (KR)
International Classes:
C12N15/40; A61K39/12; C12N1/21; C12N15/70
Foreign References:
| KR20120131533A | 2012-12-05 | |||
| US20080311143A1 | 2008-12-18 | |||
| KR20130010426A | 2013-01-28 |
Other References:
LEE, JEONG A ET AL.: "Vaccine efficacy of a chimeric mutant of porcine reproductive and respiratory syndrome virus", 2013, 4TH FALL CONFERENCE OF THE KOREAN VACCINE SOCIETY, vol. A-10, 31 August 2013 (2013-08-31), pages 78
DATABASE GENBANK 18 April 2008 (2008-04-18), "Porcine reproductive and respiratory syndrome virus strain NVSL 97-7895, complete genome", accession no. Y545985.1
TRUONG, H. M. ET AL.: "A highly pathogenic porcine reproductive and respiratory syndrome virus generated from an infectious cDNA clone retains the in vivo virulence and transmissibility properties of the parental virus", VIROGOGY, vol. 325, no. 2, 1 August 2004 (2004-08-01), pages 308 - 319, XP004520316, DOI: doi:10.1016/j.virol.2004.04.046
DATABASE GENBANK 18 April 2008 (2008-04-18), "Porcine reproductive and respiratory syndrome virus strain NVSL 97-7895, complete genome", accession no. Y545985.1
TRUONG, H. M. ET AL.: "A highly pathogenic porcine reproductive and respiratory syndrome virus generated from an infectious cDNA clone retains the in vivo virulence and transmissibility properties of the parental virus", VIROGOGY, vol. 325, no. 2, 1 August 2004 (2004-08-01), pages 308 - 319, XP004520316, DOI: doi:10.1016/j.virol.2004.04.046
Attorney, Agent or Firm:
AHN, So-Young (KR)
안소영 (KR)
안소영 (KR)
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