Title:
CHIMERIC NUCLEASE FOR SPECIFICALLY RECOGNIZING AND REPAIRING Β THALASSEMIA BETA-GLOBIN GENE
Document Type and Number:
WIPO Patent Application WO/2016/086768
Kind Code:
A1
Abstract:
Disclosed is chimeric nuclease TALE-ISceI, in which FokI in TALEN is replaced with fusion protein obtained by transformed I-SceI. The chimeric nuclease TALE-ISceI can specifically recognize and repair a β thalassemia β-globin gene and can be used for treating β-thalassemia.
Inventors:
KEE KEH KOOI (CN)
LIN JIAN FEI (CN)
LIN JIAN FEI (CN)
Application Number:
PCT/CN2015/094901
Publication Date:
June 09, 2016
Filing Date:
November 18, 2015
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
C07K19/00; A61K38/46; A61K48/00; A61P7/06; C07K14/00; C12N9/22; C12N15/62; C12N15/85
Domestic Patent References:
| WO2012149470A1 | 2012-11-01 | |||
| WO2011154927A2 | 2011-12-15 |
Foreign References:
| CN104004726A | 2014-08-27 |
Other References:
LIN, JIANFEI ET AL.: "Creating a Monomeric Endonuclease TALE-I-SceI with High Specificity and Low Genotoxicity in Human Cells", NUCLEIC ACIDS RESEARCH, vol. 43, no. 2, 24 December 2014 (2014-12-24)
Attorney, Agent or Firm:
JEEKAI & PARTNERS (CN)
北京纪凯知识产权代理有限公司 (CN)
北京纪凯知识产权代理有限公司 (CN)
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