Title:
CHIMERIC POLYPEPTIDES AND METHODS OF USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2020/172627
Kind Code:
A3
Abstract:
The present disclosure provides a chimeric polypeptide comprising at least one heterologous nuclear export signal linked to an adaptor protein of a receptor. The adaptor protein may be a Linker for Activation of T cell (LAT). The receptor may comprise a chimeric receptor.
Inventors:
YANG ZHIFEN (US)
LI LINGYU (US)
LI LINGYU (US)
Application Number:
PCT/US2020/019358
Publication Date:
October 08, 2020
Filing Date:
February 21, 2020
Export Citation:
Assignee:
REFUGE BIOTECHNOLOGIES INC (US)
International Classes:
C12N15/79; C07K14/705; C07K19/00
Foreign References:
| US20180273980A1 | 2018-09-27 | |||
| US20130115700A1 | 2013-05-09 | |||
| US20060263828A1 | 2006-11-23 |
Other References:
NAOKI KUNII, YANGBING ZHAO, SHUGUANG JIANG, XIAOJUN LIU, JOHN SCHOLLER, LAKSHMI BALAGOPALAN, LAWRENCE E. SAMELSON, MICHAEL C. MILO: "Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation", HUMAN GENE THERAPY, vol. 24, no. 1, 1 January 2013 (2013-01-01), pages 27 - 37, XP055830818, ISSN: 1043-0342, DOI: 10.1089/hum.2012.130
VISHNIVETSKIY ET AL.: "Functional rola of the three conserved cysteines in the N domain of visual arrestin-1", J BIOL CHEM., vol. 292, no. 30, 28 June 2017 (2017-06-28), pages 12496 - 12502, XP055745218
SHUKLA ET AL.: "Structure of active beta-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide", NATURE, vol. 497, no. 7447, 2 May 2013 (2013-05-02), pages 137 - 141, XP055745221
VISHNIVETSKIY ET AL.: "Functional rola of the three conserved cysteines in the N domain of visual arrestin-1", J BIOL CHEM., vol. 292, no. 30, 28 June 2017 (2017-06-28), pages 12496 - 12502, XP055745218
SHUKLA ET AL.: "Structure of active beta-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide", NATURE, vol. 497, no. 7447, 2 May 2013 (2013-05-02), pages 137 - 141, XP055745221
Attorney, Agent or Firm:
LIN, Chun Shi (US)
Download PDF: