CHIMERIC PROTEINS AND METHODS OF REGULATING GENE EXPRESSION

Title:

CHIMERIC PROTEINS AND METHODS OF REGULATING GENE EXPRESSION

Document Type and Number:

WIPO Patent Application WO/2017/123559

Kind Code:

A3

Abstract:

The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.

More Like This:

WO/2010/144485	CHEMICAL MODIFICATION MOTIFS FOR miRNA INHIBITORS AND MIMETICS
WO/2000/064480	TREATMENT, IMAGING AND DIAGNOSIS OF DISEASE USING AN AGENT WHICH BINDS ALFA5-INTEGRIN
JP7105875	Retro viral vector

Inventors:

QI LEI S (US)
DINGAL P C DAVE P (US)

Application Number:

PCT/US2017/012885

Publication Date:

August 24, 2017

Filing Date:

January 10, 2017

Export Citation:

Click for automatic bibliography generation Help

Assignee:

UNIV LELAND STANFORD JUNIOR (US)

International Classes:

C12N15/11; C12N9/22; C12N15/90

Domestic Patent References:

WO2014018423A2	2014-01-30
WO2015139139A1	2015-09-24
WO2015150771A1	2015-10-08
WO2014196932A1	2014-12-11

Foreign References:

US20150232881A1	2015-08-20
US20040197346A1	2004-10-07
US20140068797A1	2014-03-06

Other References:

KOPAN ET AL.: "The Canonical Notch Signaling Pathway: Unfolding The Activation Mechanism", CELL, vol. 137, no. 2, 2009, pages 216 - 233, XP055411700
DATABASE UniProtKB [o] 9 December 2015 (2015-12-09), ANONYMOUS, XP055576087, retrieved from UNIPROT Database accession no. Q01705

Attorney, Agent or Firm:

HAO, Joe C. et al. (US)

Download PDF:

View/Download PDF PDF Help

Previous Patent: PRINTED CIRCUIT BOARD MOUNTED ANTENNA AND WAVEGUIDE INTERFACE

Next Patent: MICROWAVE-ASSISTED CONVERSION OF CARBON DIOXIDE TO CARBON MONOXIDE