Title:
CHIMERIC PROTEINS FOR TREATMENT OF DISEASES
Document Type and Number:
WIPO Patent Application WO/2013/136180
Kind Code:
A3
Abstract:
A chimeric protein is made from the combination of (i) a pathogen recognition module derived from a scavenger receptor and (ii) an anchor domain from a different scavenger receptor. The chimeric protein binds to specific pathogens and is useful in various treatments.
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Inventors:
TRYGGVASSON KARL (SE)
PIKKARAINEN TIMO (SE)
OJALA JUHA (SE)
AXELSSON JONAS (SE)
PIKKARAINEN TIMO (SE)
OJALA JUHA (SE)
AXELSSON JONAS (SE)
Application Number:
PCT/IB2013/000845
Publication Date:
December 05, 2013
Filing Date:
March 12, 2013
Export Citation:
Assignee:
SCARATECH MEDICAL AB (SE)
International Classes:
C07K14/705; C12N15/62; G01N33/569
Domestic Patent References:
| WO2002035236A1 | 2002-05-02 | |||
| WO1998047916A1 | 1998-10-29 |
Foreign References:
| US20060057625A1 | 2006-03-16 | |||
| EP0808899A2 | 1997-11-26 |
Other References:
MUKHOPADHYAY S ET AL: "The role of scavenger receptors in pathogen recognition and innate immunity", IMMUNOBIOLOGY, URBAN UND FISCHER VERLAG, DE, vol. 209, no. 1-2, 23 August 2004 (2004-08-23), pages 39 - 49, XP004954235, ISSN: 0171-2985, DOI: 10.1016/J.IMBIO.2004.02.004
ADACHI H ET AL: "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 277, no. 37, 13 September 2002 (2002-09-13), pages 34264 - 34270, XP002231165, ISSN: 0021-9258, DOI: 10.1074/JBC.M204277200
THOMAS ARESCHOUG ET AL: "Scavenger receptors: role in innate immunity and microbial pathogenesis", CELLULAR MICROBIOLOGY, vol. 11, no. 8, 1 August 2009 (2009-08-01), pages 1160 - 1169, XP055077616, ISSN: 1462-5814, DOI: 10.1111/j.1462-5822.2009.01326.x
DUNNE D W ET AL: "The type I macrophage scavenger receptor binds to gram-positive bacteria and recognizes lipoteichoic acid.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1 MAR 1994, vol. 91, no. 5, 1 March 1994 (1994-03-01), pages 1863 - 1867, XP002004772, ISSN: 0027-8424
ANNETTE PLÜDDEMANN ET AL: "The Macrophage Scavenger Receptor A Is Host-Protective in Experimental Meningococcal Septicaemia", PLOS PATHOGENS, vol. 5, no. 2, 1 February 2009 (2009-02-01), pages e1000297 - e1000297, XP055077618, ISSN: 1553-7366, DOI: 10.1371/journal.ppat.1000297
M. SANKALA: "Characterization of Recombinant Soluble Macrophage Scavenger Receptor MARCO", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 36, 30 August 2002 (2002-08-30), pages 33378 - 33385, XP055077678, ISSN: 0021-9258, DOI: 10.1074/jbc.M204494200
Y. CHEN: "A Phage Display Screen and Binding Studies with Acetylated Low Density Lipoprotein Provide Evidence for the Importance of the Scavenger Receptor Cysteine-rich (SRCR) Domain in the Ligand-binding Function of MARCO", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, no. 18, 23 February 2006 (2006-02-23), pages 12767 - 12775, XP055077649, ISSN: 0021-9258, DOI: 10.1074/jbc.M513628200
PLUDDEMANN ET AL: "A sensitive solid-phase assay for identification of class A macrophage scavenger receptor ligands using cell lysate", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 329, no. 1-2, 25 October 2007 (2007-10-25), pages 167 - 175, XP022389340, ISSN: 0022-1759
J. R. M. OJALA ET AL: "Crystal Structure of the Cysteine-rich Domain of Scavenger Receptor MARCO Reveals the Presence of a Basic and an Acidic Cluster That Both Contribute to Ligand Recognition", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 22, 1 June 2007 (2007-06-01), pages 16654 - 16666, XP055077748, ISSN: 0021-9258, DOI: 10.1074/jbc.M701750200
ADACHI H ET AL: "FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 277, no. 37, 13 September 2002 (2002-09-13), pages 34264 - 34270, XP002231165, ISSN: 0021-9258, DOI: 10.1074/JBC.M204277200
THOMAS ARESCHOUG ET AL: "Scavenger receptors: role in innate immunity and microbial pathogenesis", CELLULAR MICROBIOLOGY, vol. 11, no. 8, 1 August 2009 (2009-08-01), pages 1160 - 1169, XP055077616, ISSN: 1462-5814, DOI: 10.1111/j.1462-5822.2009.01326.x
DUNNE D W ET AL: "The type I macrophage scavenger receptor binds to gram-positive bacteria and recognizes lipoteichoic acid.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1 MAR 1994, vol. 91, no. 5, 1 March 1994 (1994-03-01), pages 1863 - 1867, XP002004772, ISSN: 0027-8424
ANNETTE PLÜDDEMANN ET AL: "The Macrophage Scavenger Receptor A Is Host-Protective in Experimental Meningococcal Septicaemia", PLOS PATHOGENS, vol. 5, no. 2, 1 February 2009 (2009-02-01), pages e1000297 - e1000297, XP055077618, ISSN: 1553-7366, DOI: 10.1371/journal.ppat.1000297
M. SANKALA: "Characterization of Recombinant Soluble Macrophage Scavenger Receptor MARCO", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 36, 30 August 2002 (2002-08-30), pages 33378 - 33385, XP055077678, ISSN: 0021-9258, DOI: 10.1074/jbc.M204494200
Y. CHEN: "A Phage Display Screen and Binding Studies with Acetylated Low Density Lipoprotein Provide Evidence for the Importance of the Scavenger Receptor Cysteine-rich (SRCR) Domain in the Ligand-binding Function of MARCO", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, no. 18, 23 February 2006 (2006-02-23), pages 12767 - 12775, XP055077649, ISSN: 0021-9258, DOI: 10.1074/jbc.M513628200
PLUDDEMANN ET AL: "A sensitive solid-phase assay for identification of class A macrophage scavenger receptor ligands using cell lysate", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 329, no. 1-2, 25 October 2007 (2007-10-25), pages 167 - 175, XP022389340, ISSN: 0022-1759
J. R. M. OJALA ET AL: "Crystal Structure of the Cysteine-rich Domain of Scavenger Receptor MARCO Reveals the Presence of a Basic and an Acidic Cluster That Both Contribute to Ligand Recognition", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 22, 1 June 2007 (2007-06-01), pages 16654 - 16666, XP055077748, ISSN: 0021-9258, DOI: 10.1074/jbc.M701750200
Attorney, Agent or Firm:
KLEIN, Richard, M. (The Halle Building 5th Floo, Cleveland OH, US)
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