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Title:
CHIMERIC RECEPTORS AND METHOD OF SCREENING LIGANDS OR INHIBITORS FOR THE RECEPTORS
Document Type and Number:
WIPO Patent Application WO/2004/078972
Kind Code:
A1
Abstract:
By constructing a human NPR-A/mouse G-CSFR chimeric receptor expression vector and a human NPR-B/mouse G-CSFR chimeric receptor expression vector and transferring them into mouse Ba/F3 cells, a chimeric ANP receptor-expressing cell line highly sensitive to human ANP and a chimeric CNP receptor-expressing cell line highly sensitive to human CNP are successfully obtained respectively. Use of these cells makes it possible to screen ligands or inhibitors for these chimeric receptors.

Inventors:
Suzuki, Yoshiyuki c/o Chugai Seiyaku Kabushiki Kaisha (135 Komakado 1-chome, Gotenba-sh, Shizuoka 38, 41200, JP)
Kojima, Tetsuo c/o Chugai Seiyaku Kabushiki Kaisha (135 Komakado 1-chome, Gotenba-sh, Shizuoka 38, 41200, JP)
Sato, Taiji c/o Chugai Seiyaku Kabushiki Kaisha (135 Komakado 1-chome, Gotenba-sh, Shizuoka 38, 41200, JP)
Senoo, Chiaki c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (135 Komakado, 1-chom, Gotenba-shi Shizuoka 38, 41200, JP)
Kimura, Naoki c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (153-2 Nagai, Niihari-mur, Niihari-gun Ibaraki 01, 30041, JP)
Application Number:
PCT/JP2004/002919
Publication Date:
September 16, 2004
Filing Date:
March 05, 2004
Export Citation:
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Assignee:
CHUGAI SEIYAKU KABUSHIKI KAISHA (5-1 Ukima 5-chome, Kita-ku Tokyo, 43, 11585, JP)
Suzuki, Yoshiyuki c/o Chugai Seiyaku Kabushiki Kaisha (135 Komakado 1-chome, Gotenba-sh, Shizuoka 38, 41200, JP)
Kojima, Tetsuo c/o Chugai Seiyaku Kabushiki Kaisha (135 Komakado 1-chome, Gotenba-sh, Shizuoka 38, 41200, JP)
Sato, Taiji c/o Chugai Seiyaku Kabushiki Kaisha (135 Komakado 1-chome, Gotenba-sh, Shizuoka 38, 41200, JP)
Senoo, Chiaki c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (135 Komakado, 1-chom, Gotenba-shi Shizuoka 38, 41200, JP)
Kimura, Naoki c/o CHUGAI SEIYAKU KABUSHIKI KAISHA (153-2 Nagai, Niihari-mur, Niihari-gun Ibaraki 01, 30041, JP)
International Classes:
C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N15/12; G01N33/566; (IPC1-7): C12N15/09; C07K14/705; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12Q1/02
Domestic Patent References:
WO1994029458A1
WO2002006838A1
Attorney, Agent or Firm:
Shimizu, Hatsushi (Kantetsu Tsukuba Bldg. 6f 1-1-1, Oroshi-machi Tsuchiura-sh, Ibaraki 47, 30008, JP)
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