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Patent Searching and Data


Title:
CHIMERIC RECEPTORS AND METHOD OF SCREENING LIGANDS OR INHIBITORS FOR THE RECEPTORS
Document Type and Number:
WIPO Patent Application WO/2004/078972
Kind Code:
A1
Abstract:
By constructing a human NPR-A/mouse G-CSFR chimeric receptor expression vector and a human NPR-B/mouse G-CSFR chimeric receptor expression vector and transferring them into mouse Ba/F3 cells, a chimeric ANP receptor-expressing cell line highly sensitive to human ANP and a chimeric CNP receptor-expressing cell line highly sensitive to human CNP are successfully obtained respectively. Use of these cells makes it possible to screen ligands or inhibitors for these chimeric receptors.

Inventors:
SUZUKI YOSHIYUKI (JP)
KOJIMA TETSUO (JP)
SATO TAIJI (JP)
SENOO CHIAKI (JP)
KIMURA NAOKI (JP)
Application Number:
PCT/JP2004/002919
Publication Date:
September 16, 2004
Filing Date:
March 05, 2004
Export Citation:
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Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
SUZUKI YOSHIYUKI (JP)
KOJIMA TETSUO (JP)
SATO TAIJI (JP)
SENOO CHIAKI (JP)
KIMURA NAOKI (JP)
International Classes:
C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N15/12; G01N33/566; (IPC1-7): C12N15/09; C12N15/12; C07K14/705; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/02
Domestic Patent References:
WO1994029458A11994-12-22
WO2002006838A12002-01-24
Attorney, Agent or Firm:
Shimizu, Hatsushi (Oroshi-machi Tsuchiura-sh, Ibaraki 47, JP)
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