Title:
CHIMERIC RECEPTORS AND METHOD OF SCREENING LIGANDS OR INHIBITORS FOR THE RECEPTORS
Document Type and Number:
WIPO Patent Application WO/2004/078972
Kind Code:
A1
Abstract:
By constructing a human NPR-A/mouse G-CSFR chimeric receptor expression vector and a human NPR-B/mouse G-CSFR chimeric receptor expression vector and transferring them into mouse Ba/F3 cells, a chimeric ANP receptor-expressing cell line highly sensitive to human ANP and a chimeric CNP receptor-expressing cell line highly sensitive to human CNP are successfully obtained respectively. Use of these cells makes it possible to screen ligands or inhibitors for these chimeric receptors.
Inventors:
SUZUKI YOSHIYUKI (JP)
KOJIMA TETSUO (JP)
SATO TAIJI (JP)
SENOO CHIAKI (JP)
KIMURA NAOKI (JP)
KOJIMA TETSUO (JP)
SATO TAIJI (JP)
SENOO CHIAKI (JP)
KIMURA NAOKI (JP)
Application Number:
PCT/JP2004/002919
Publication Date:
September 16, 2004
Filing Date:
March 05, 2004
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
SUZUKI YOSHIYUKI (JP)
KOJIMA TETSUO (JP)
SATO TAIJI (JP)
SENOO CHIAKI (JP)
KIMURA NAOKI (JP)
SUZUKI YOSHIYUKI (JP)
KOJIMA TETSUO (JP)
SATO TAIJI (JP)
SENOO CHIAKI (JP)
KIMURA NAOKI (JP)
International Classes:
C07K14/705; C12N1/15; C12N1/19; C12N1/21; C12N15/12; G01N33/566; (IPC1-7): C12N15/09; C07K14/705; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12Q1/02
Domestic Patent References:
| WO1994029458A1 | 1994-12-22 | |||
| WO2002006838A1 | 2002-01-24 |
Attorney, Agent or Firm:
Shimizu, Hatsushi (Oroshi-machi Tsuchiura-sh, Ibaraki 47, JP)
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