Title:
CHIMERIC TARGET MOLECULES HAVING A REGULATABLE ACTIVITY
Document Type and Number:
WIPO Patent Application WO1998023731
Kind Code:
A3
Abstract:
The present invention relates to a chimeric target molecule having an activity which can be regulated or modulated by a binding molecule. The invention also relates to methods of using the chimeric target molecule to detect the presence and/or amount of a desired analyte in a sample. The analyte is a binding molecule, or a competitor of a binding molecule, which binding molecule, upon binding to the target molecule, alters the activity of the target molecule in a detectable way. In one aspect of the invention, a binding molecule binds to the chimeric molecule, inactivating it. An analyte in a test sample competes and/or displaces the binding molecule from the chimera, reactivating it. The reappearance of activity in the presence of the analyte indicates its existence in the test sample existence and amount. Another aspect of the invention relates to a binding molecule which regulates a chimeric target molecule and methods of producing it.
Inventors:
LEGENDRE DANIEL
SOUMILLION PATRICE
FASTREZ JACQUES
SOUMILLION PATRICE
FASTREZ JACQUES
Application Number:
PCT/IB1997/001643
Publication Date:
November 12, 1998
Filing Date:
November 26, 1997
Export Citation:
Assignee:
UNIV CATHOLIQUE LOUVAIN (BE)
International Classes:
C12N9/00; G01N33/573; C12N9/86; C12N15/09; C12N15/62; C12Q1/00; G01N33/542; (IPC1-7): C12N9/00
Domestic Patent References:
| WO1996017870A1 | 1996-06-13 | |||
| WO1988002757A1 | 1988-04-21 | |||
| WO1993022450A1 | 1993-11-11 |
Other References:
See also references of EP 0958351A2
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