CHIP FOR DETECTING GENETIC MUTATION OF CYTOCHROME P450 GENE AND THE USE THEREOF

Title:

CHIP FOR DETECTING GENETIC MUTATION OF CYTOCHROME P450 GENE AND THE USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2008/011787

Kind Code:

A8

Abstract:

A chip for detecting genetic mutation of cytochrome P450 gene is provided. The chip comprises a solid carrier and probes. The probes can hybridize to the nucleotide sequence and/or its complementary sequence of the cytochrome P450 gene to be detected. Also provided is a method of detecting genetic mutation of cytochrome P450 gene by the chip. The chip can be used to effectively detect the genetic mutation of CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5 and CYP3A7, and predict the therapeutic efficiency of above 40% of clinical medicaments to realize individuation of medical treatment.

Inventors:

SHENG HAIHUI (CN)
XIAO HUASHENG (CN)

Application Number:

PCT/CN2007/001853

Publication Date:

July 09, 2009

Filing Date:

June 12, 2007

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Assignee:

SHANGHAI BIOCHIP CO LTD (CN)
SHENG HAIHUI (CN)
XIAO HUASHENG (CN)

International Classes:

C12Q1/68

Attorney, Agent or Firm:

DING & ASSOCIATES PATENT TRADEMARK & LAW (Zhang Jiang High-Tech Zone, Shanghai 3, CN)

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