Title:
CHIRAL 1,8-DIARYLNAPHTHALENES, METHODS OF MAKING THEM, AND THEIR USE AS SENSORS
Document Type and Number:
WIPO Patent Application WO2005043124
Kind Code:
A3
Abstract:
One aspect of the invention relates to 1,8-diarylnaphthalene compounds. In certain embodiments, a compound of the invention is an N-oxide of a 1,8-diarylnaphthalene. In certain embodiments, the aryl group is an optionally substituted acridyl group. In certain embodiments, a compound of the invention is a single steroisomer. In certain embodiments, a compound of the invention is a single enantiomer. Another aspect of the present invention relates to a method of detecting the presence of an analyte in a sample by monitoring the fluorescence of a compound of the invention in a sample. In certain embodiments, the analyte is a metal ion. Another aspect of the present invention relates to a method of determining the enantiomeric purity of an analyte by monitoring the fluorescence of a compound of the invention in the presence of the analyte. In certain embodiments, the analyte is a compound that is capable of hydrogen bonding.
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Inventors:
WOLF CHRISTIAN (US)
MEI XUEFENG (US)
MEI XUEFENG (US)
Application Number:
PCT/US2004/036409
Publication Date:
July 21, 2005
Filing Date:
November 01, 2004
Export Citation:
Assignee:
UNIV GEORGETOWN (US)
WOLF CHRISTIAN (US)
MEI XUEFENG (US)
WOLF CHRISTIAN (US)
MEI XUEFENG (US)
International Classes:
A61K31/395; A61K31/44; A61K31/47; C07D213/02; C07D213/16; C07D213/89; C07D215/00; C07D217/00; C07D219/02; C07D221/18; C07D307/00; C07D401/02; G01N33/52; G01N; (IPC1-7): A61K31/395; A61K31/44; A61K31/47; C07D213/02; C07D215/00; C07D217/00; C07D401/02
Foreign References:
| US6214324B1 | 2001-04-10 |
Other References:
WOLF C. ET AL: "Synthesis of Conformationally Stable 1,8-Diarylnaphthalenes: Development of New Photoluminescent Sensors for Lon-Selective Recognition", JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 125, no. 35, 2003, pages 10651 - 10658, XP002987274
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