Title:
CHIRAL DETERMINATION USING HALF-FREQUENCY SPECTRAL SIGNATURES
Document Type and Number:
WIPO Patent Application WO/2013/144673
Kind Code:
A8
Abstract:
A technique for determining whether or not a fluorescent material exhibits a directionally dependent property, such as anisotropy or chirality, involves illuminating the particle at its excitation wavelength to stimulate fluorescent emission at both a full-frequency (fundamental) wavelength and a half-frequency wavelength. The ratio of the full-frequency signal strength to the half-frequency signal strength provides an indication of the sample's directionally dependent property. This half-frequency spectral analysis can be used to sort anisotropic particles suspended in fluid flowing through a flow cytometer. For instance, the present technique may be used to separate racemic mixtures of chiral enantiomers of cells, pharmaceutical compounds, and other samples.
Inventors:
DASGUPTA ANJAN KR (IN)
ROY SARITA (IN)
ROY SARITA (IN)
Application Number:
PCT/IB2012/001499
Publication Date:
November 28, 2013
Filing Date:
August 06, 2012
Export Citation:
Assignee:
UNIV CALCUTTA (IN)
DASGUPTA ANJAN KR (IN)
ROY SARITA (IN)
DASGUPTA ANJAN KR (IN)
ROY SARITA (IN)
International Classes:
G01N21/64; G01N15/14; G01N21/21
Attorney, Agent or Firm:
NAIR, Manoj, Vasudevan (709/710 Tolstoy House,15-17 Tolstoy Marg, New Delhi - 1, IN)
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