Title:
CHIRAL REDUCING AGENT AND METHOD FOR SYNTHESIZING CHIRAL NICOTINE
Document Type and Number:
WIPO Patent Application WO/2024/077407
Kind Code:
A1
Abstract:
Disclosed in the present invention are a chiral reducing agent and a method for synthesizing chiral nicotine. The chiral reducing agent is a compound 1 or a compound 2, or a stereoisomer of the compound 1 and the compound 2. The structural formulae of the compound 1 and the compound 2 are as shown below, wherein a substituent group Ar is phenyl, 1-naphthyl or 2-naphthyl. In the present invention, the chiral reducing agent, i.e., the compound 1 or the compound 2, is used for reducing dehydronicotine in the presence of a solvent, and the resulting product is hydrolyzed to obtain chiral nicotine. In the present invention, by using the chiral reducing agent, dehydronicotine can be reduced by means of chiral reducing agents 1 and 2, and then subjected to a hydrolysis reaction, so as to prepare chiral nicotine. The starting raw material has a low price, the reaction conditions are mild, and the synthesis yield and optical purity of nicotine are high.
Inventors:
TAN PINGZHONG (CN)
TAN PINGAN (CN)
WANG LIMIN (CN)
DENG QIAN (CN)
CHEN LIN (CN)
KANG SHAODONG (CN)
SUN LINJIE (CN)
HU NA (CN)
TAN PINGAN (CN)
WANG LIMIN (CN)
DENG QIAN (CN)
CHEN LIN (CN)
KANG SHAODONG (CN)
SUN LINJIE (CN)
HU NA (CN)
Application Number:
PCT/CN2022/123930
Publication Date:
April 18, 2024
Filing Date:
October 09, 2022
Export Citation:
Assignee:
CHENGDU ORGANOCHEM CO LTD (CN)
International Classes:
C07F5/02; C07D401/04
Attorney, Agent or Firm:
CHENGDU XINGZHI PATENT AGENCY (ORDINARY PARTNERSHIP) (CN)
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