CHIRAL RESOLUTION METHOD OF N-[4-(1-AMINOETHYL)-PHENYL]-SULFONAMIDE DERIVATIVES

Title:

CHIRAL RESOLUTION METHOD OF N-[4-(1-AMINOETHYL)-PHENYL]-SULFONAMIDE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/2016/133317

Kind Code:

A1

Abstract:

The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in which an amine group is bound to an asymmetric carbon atom, with a chiral auxiliary and salt-forming auxiliary compound, wherein the chiral auxiliary is an O,O'-diacyltartaric acid derivative, more specifically, a 2,3-dibenzoyl-tartaric acid or an O,O'-di-p-toluoyl tartaric acid, the salt-forming auxiliary compound is mandelic acid or camphorsulfonic acid, and an optical isomer having a high level of optical purity can be obtained by using the method. Therefore, according to one aspect of the present invention, the method can be useful in the pharmaceutical or cosmetic field when preparing an optical isomer having a high optical purity.

Inventors:

WOO BYOUNG YOUNG (KR)
LEE KI-WHA (KR)
SHIN KWANG-HYUN (KR)
PARK MIYOUNG (KR)
JUNG KYOUNGMI (KR)
CHOI JOONHO (KR)
CHOI GYEYOUNG (KR)
CHO WONKYUNG (KR)
PARK YOUNG-HO (KR)

Application Number:

PCT/KR2016/001474

Publication Date:

August 25, 2016

Filing Date:

February 15, 2016

Export Citation:

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Assignee:

AMOREPACIFIC CORP (KR)

International Classes:

C07C303/36; C07C303/42; C07C311/08

Foreign References:

KR20080002931A	2008-01-04
KR20090033916A	2009-04-06
KR20020051937A	2002-06-29
US4968837A	1990-11-06

Other References: