Title:
CHIRAL RESOLUTION METHOD FOR N-[4-(1-AMINOETHYL)-PHENYL]-SULFONAMIDE DERIVATIVE USING POLAR APROTIC SOLVENT
Document Type and Number:
WIPO Patent Application WO/2017/119666
Kind Code:
A1
Abstract:
The present invention relates to a chiral resolution method for a stereoisomeric mixture, the method comprising a step for mixing a stereoisomeric mixture of a compound, in which an amine group is attached to an asymmetric carbon atom, and a chiral auxiliary. Here, the chiral auxiliary is 2,3-dibenzoyl-tartaric acid or O,O'-di-p-toluoyl tartaric acid. An optical isomer having a high level of optical purity may be obtained by this method. Moreover, according to this method, the ratio of the stereoisomeric mixture contained in a mother liquid may be adjusted through recovery of the optical isomer. Therefore, in the pharmaceutical or medicinal field, a method according to an aspect of the present invention may be usefully used when attempting to obtain at high purity, a compound having a single type of optical isomer, and may be usefully used in the racemization of a mother liquid used in another reaction.
Inventors:
WOO BYOUNG YOUNG (KR)
LEE KI-WHA (KR)
ROH JONG HWA (KR)
PARK JAE HONG (KR)
PARK MIYOUNG (KR)
PARK YOUNG-HO (KR)
LEE KI-WHA (KR)
ROH JONG HWA (KR)
PARK JAE HONG (KR)
PARK MIYOUNG (KR)
PARK YOUNG-HO (KR)
Application Number:
PCT/KR2016/015402
Publication Date:
July 13, 2017
Filing Date:
December 28, 2016
Export Citation:
Assignee:
AMOREPACIFIC CORP (KR)
International Classes:
C07C303/36; C07C311/08; C07D213/26; C07D213/61
Foreign References:
| KR20080002931A | 2008-01-04 | |||
| KR20090033916A | 2009-04-06 | |||
| US20070185346A1 | 2007-08-09 | |||
| KR20020051937A | 2002-06-29 | |||
| US4968837A | 1990-11-06 | |||
| KR20160101554A | 2016-08-25 |
Attorney, Agent or Firm:
KIM, Sun-young (KR)
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