Title:
A CHIRAL SELECTOR USEFUL FOR SEPARATION OF ENANTIOMERS OF BETA-AMINO ALCOHOL COMPOUNDS
Document Type and Number:
WIPO Patent Application WO1993006111
Kind Code:
A3
Abstract:
The present invention relates to the separation of beta -amino alcohol compounds, particularly compounds known as beta -blockers, by employing what is known as a chiral selector compound which can achieve separation of enantiomers without requiring derivatization of the enantiomers before effecting separation.
Inventors:
PIRKLE WILLIAM H (US)
BURKE JOHN A III (US)
LEE WONJAE (US)
BURKE JOHN A III (US)
LEE WONJAE (US)
Application Number:
PCT/US1992/007878
Publication Date:
June 10, 1993
Filing Date:
September 17, 1992
Export Citation:
Assignee:
PIRKLE WILLIAM H (US)
BURKE JOHN A III (US)
LEE WONJAE (US)
BURKE JOHN A III (US)
LEE WONJAE (US)
International Classes:
C07D205/085; C07F7/18; C07F9/40; (IPC1-7): C07F9/40; C07D205/085; B01D15/08; C07B57/00
Other References:
Journal of Chromatography, vol. 557, 20 September 1991, Elsevier Science Publishers B.V., W.H. PIRKLE et al.: "Chiral stationary phase designed for beta-blockers", pages 173-185, see the whole article
Chirality, vol. 1, 1989, Alan R. Liss, Inc., W.H. PIRKLE et al.: "Preparation of a chiral stationary phase from an alpha-amino phosphonate", pages 57-62, see table 1
Patent Abstracts of Japan, vol. 15, no. 445 (C-884), & JP,A,03190827 (NIPPON STEEL CORP.) 20 August 1991
Journal of Pharmaceutical & Biomedical Analysis, vol. 2, no. 2, 1984, Pergamon Press Ltd, (GB), W.H. PIRKLE et al.: "A rational approach to the design of highly effective chiral stationary phases for the liquid chromatographic separation of enantiomers", pages 173-181, see the whole article
Journal of Chromatography, Volume 441, No. 2, 1988, W.H. Pirkle et al, "An improved chiral stationary phase for the facile separation of enantiomers"
Chirality, vol. 1, 1989, Alan R. Liss, Inc., W.H. PIRKLE et al.: "Preparation of a chiral stationary phase from an alpha-amino phosphonate", pages 57-62, see table 1
Patent Abstracts of Japan, vol. 15, no. 445 (C-884), & JP,A,03190827 (NIPPON STEEL CORP.) 20 August 1991
Journal of Pharmaceutical & Biomedical Analysis, vol. 2, no. 2, 1984, Pergamon Press Ltd, (GB), W.H. PIRKLE et al.: "A rational approach to the design of highly effective chiral stationary phases for the liquid chromatographic separation of enantiomers", pages 173-181, see the whole article
Journal of Chromatography, Volume 441, No. 2, 1988, W.H. Pirkle et al, "An improved chiral stationary phase for the facile separation of enantiomers"
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