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Title:
CHIRAL SEPARATION AND ANALYSIS BY MOLECULAR PROPELLER EFFECT
Document Type and Number:
WIPO Patent Application WO/2017/003909
Kind Code:
A3
Abstract:
A method and a device for separation and analysis of chiral molecules are described. The method relies on using a fluid shear to induce molecular rotation and the molecular propeller effect to transform rotational motion into translation motion of opposite direction for counterpart enantiomers. The direction of motion of each enantiomers is used to determine its absolute configuration by comparing the direction value with theoretically calculated one. The device uses multiple moving surfaces or pressure induced flows to induce shear flow condition in the solution to separate enantiomers.

Inventors:
CHACHISVILIS, Mirianas (4744 Keswick Court, San Diego, CA, 92130, US)
Application Number:
US2016/039505
Publication Date:
February 16, 2017
Filing Date:
June 27, 2016
Export Citation:
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Assignee:
CHACHISVILIS, Mirianas (4744 Keswick Court, San Diego, CA, 92130, US)
International Classes:
C07B57/00; C07C231/20
Domestic Patent References:
WO2016020532A12016-02-11
Foreign References:
JP2005145887A2005-06-09
US20080274555A12008-11-06
US6344121B12002-02-05
Other References:
MEINHARDT ET AL.: "Separation of Chiral Particles in Micro- or Nanofluidic Channels", PHYSICAL REVIEW LETTERS, vol. 108, no. Issue 21, 23 May 2012 (2012-05-23), pages 214504-1 - 214504-5, XP055364102
HERMANS ET AL.: "Vortex flows impart chirality-specific lift forces", NATURE COMMUNICATIONS, vol. 6, 12 January 2015 (2015-01-12), pages 1 - 8, XP055364104
SCHAMEL ET AL.: "Chiral Colloidal Molecules And Observation of The Propeller Effect", vol. 135, no. Issue 33, 24 July 2013 (2013-07-24), pages 12353 - 12359, XP055364110
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