Title:
CHIRAL SPIRO COMPOUNDS AND THEIR USE IN ASYMMETRIC CATALYTIC REACTIONS
Document Type and Number:
WIPO Patent Application WO2006028977
Kind Code:
A3
Abstract:
The present invention provides a chiral ligand, represented by a formula or its enantiomer: formula (I) X and X' can be independently O, NH, NR, NCOR or S; each of Z1-Z7 and Z1'-Z7' can be independently H, alkyl, aryl, substituted alkyl, substituted aryl, alkoxyl, aryloxyl, nitro, amide, aryoxide, halide, hydroxyl, carboxylate, hetereoaryl, or a cyclic alkene, fused aryl, or cyclic ether group formed to from any two adjacent Z groups or any two adjacent Z' groups; Y and Y' can be independently OH, OR, NH2, NHR, NR2, SH, PR2, OPR2, NHPR2, OP(OR)2, COOH, COOK, CONHR, or a linking group formed from Y and Y' groups together. Processes of preparing these ligands, catalysts that employ them and methods of using the catalysts are also provided.
Inventors:
ZHANG XUMU (US)
Application Number:
PCT/US2005/031341
Publication Date:
August 17, 2006
Filing Date:
September 01, 2005
Export Citation:
Assignee:
PENN STATE RES FOUND (US)
ZHANG XUMU (US)
ZHANG XUMU (US)
International Classes:
C07D209/96; C07D307/94; C07D339/02; C07D409/02; C07D487/10; C07D493/18; C07D495/10; C07F9/547
Foreign References:
| JP2002265938A | 2002-09-18 |
Other References:
ZHAND ET AL.: "Highly Enantioselective Copper-Catalyzed Conjugate Addition of Diethylzin to Cyclic Enones with Spirocyclic Phosphoramidite Ligands", TETRAHEDRON LETTERS, vol. 46, no. 36, September 2005 (2005-09-01), pages 6087 - 6090, XP005003082
WU ET AL.: "Synthesis of New Monodentate Spiro Phosphoramidite Ligand and its Application in Rh-Catalyzed Asymmetric hydrogenation Reaction", ORGANIC LETTERS, vol. 6, no. 20, 10 September 2004 (2004-09-10), pages 3565 - 3567, XP003001738
WU ET AL.: "Synthesis of New Monodentate Spiro Phosphoramidite Ligand and its Application in Rh-Catalyzed Asymmetric hydrogenation Reaction", ORGANIC LETTERS, vol. 6, no. 20, 10 September 2004 (2004-09-10), pages 3565 - 3567, XP003001738
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