Title:
CHLOROHYDROXYACETONE DERIVATIVE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE CHLOROPROPANEDIOL DERIVATIVE FROM THE SAME
Document Type and Number:
WIPO Patent Application WO/2002/000585
Kind Code:
A1
Abstract:
A process for efficiently producing an optically active chloropropanediol derivative, especially (S)-1-benzyloxy-3-chloro-2-propanol, which has a high optical purity and is useful as an intermediate for medicines. The process comprises treating an inexpensive racemic chloropropanediol derivative with a nitroxyl compound and an oxidizing agent to convert it into a chlorohydroxyacetone derivative and then stereospecifically reducing the carbonyl group of the chlorohydroxyacetone derivative by the action of either a carbonyl-reducing enzyme having the ability to stereospecifically reduce the chlorohydroxyacetone derivative or an optionally treated culture of a microorganism having the ability to yield the carbonyl-reducing enzyme. Thus, an optically active chloropropanediol derivative is produced.
Inventors:
Taoka, Naoaki (1-1-A-1210, Doshodai Suma-ku Kobe-shi, Hyogo, 654-0122, JP)
Maeda, Hironobu (Sanseiso, 6-31-17 Shioya-ch, Tarumi-ku Kobe-shi Hyogo, 655-0872, JP)
Okuro, Kazumi (1-1-1-1303, Gakuennishimachi Nishi-ku Kobe-shi, Hyogo, 651-2103, JP)
Toyota, Koichiro (3-3-26-107, Nishiakashikitamachi Akashi-shi, Hyogo, 673-0018, JP)
Yasohara, Yoshihiko (3-7-2-605, Hinode-cho Himeji-shi, Hyogo, 670-0942, JP)
Maeda, Hironobu (Sanseiso, 6-31-17 Shioya-ch, Tarumi-ku Kobe-shi Hyogo, 655-0872, JP)
Okuro, Kazumi (1-1-1-1303, Gakuennishimachi Nishi-ku Kobe-shi, Hyogo, 651-2103, JP)
Toyota, Koichiro (3-3-26-107, Nishiakashikitamachi Akashi-shi, Hyogo, 673-0018, JP)
Yasohara, Yoshihiko (3-7-2-605, Hinode-cho Himeji-shi, Hyogo, 670-0942, JP)
Application Number:
PCT/JP2001/005363
Publication Date:
January 03, 2002
Filing Date:
June 22, 2001
Export Citation:
Assignee:
KANEKA CORPORATION (2-4 Nakanoshima 3-chome, Kita-ku Osaka-shi, Osaka, 530-8288, JP)
Taoka, Naoaki (1-1-A-1210, Doshodai Suma-ku Kobe-shi, Hyogo, 654-0122, JP)
Maeda, Hironobu (Sanseiso, 6-31-17 Shioya-ch, Tarumi-ku Kobe-shi Hyogo, 655-0872, JP)
Okuro, Kazumi (1-1-1-1303, Gakuennishimachi Nishi-ku Kobe-shi, Hyogo, 651-2103, JP)
Toyota, Koichiro (3-3-26-107, Nishiakashikitamachi Akashi-shi, Hyogo, 673-0018, JP)
Yasohara, Yoshihiko (3-7-2-605, Hinode-cho Himeji-shi, Hyogo, 670-0942, JP)
Taoka, Naoaki (1-1-A-1210, Doshodai Suma-ku Kobe-shi, Hyogo, 654-0122, JP)
Maeda, Hironobu (Sanseiso, 6-31-17 Shioya-ch, Tarumi-ku Kobe-shi Hyogo, 655-0872, JP)
Okuro, Kazumi (1-1-1-1303, Gakuennishimachi Nishi-ku Kobe-shi, Hyogo, 651-2103, JP)
Toyota, Koichiro (3-3-26-107, Nishiakashikitamachi Akashi-shi, Hyogo, 673-0018, JP)
Yasohara, Yoshihiko (3-7-2-605, Hinode-cho Himeji-shi, Hyogo, 670-0942, JP)
International Classes:
C07C45/29; C07C49/255; C12P7/04; C12P7/18; C12P7/26; C12P41/00; (IPC1-7): C07C49/175; C07C69/78; C07C45/29; C07C67/29; C07C309/73; C07C303/30; C12P7/02
Attorney, Agent or Firm:
Asahina, Sohta (NS Building, 2-22 Tanimachi 2-chom, Chuo-ku Osaka-shi Osaka, 540-0012, JP)
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