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Title:
CHLORPROTHIXENE PHARMACEUTICAL COMPOSITION AND EFFECTS THEREOF FOR PROTECTING CEREBRAL ISCHEMIA REPERFUSION INJURIES
Document Type and Number:
WIPO Patent Application WO/2017/215680
Kind Code:
A3
Abstract:
Disclosed are a chlorprothixene pharmaceutical composition and effects thereof for protecting cerebral ischemia reperfusion injuries. The chlorprothixene pharmaceutical composition provided in the present invention comprises chlorprothixene and a naturally produced compound (I) having a new structure and isolated from Radix Adenophorae. When used independently, chlorprothixene and the natural product can reduce cerebral ischemia reperfusion injuries. When the two are used in conjunction, the cerebral ischemia reperfusion injuries preventing and treating effects are better, which can be developed into medications for preventing and treating cerebral ischemia reperfusion injuries. Compared to prior art, the present invention is more substantive and shows significant improvement.

Inventors:
CUI KUNFENG (CN)
Application Number:
PCT/CN2017/097017
Publication Date:
February 15, 2018
Filing Date:
August 11, 2017
Export Citation:
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Assignee:
ZHAO JIYONG (CN)
International Classes:
C07D311/76; A61K31/352; A61K31/382; A61P9/10
Foreign References:
CN106083800A2016-11-09
CN105837595A2016-08-10
CN105111275A2015-12-02
CN105017276A2015-11-04
CN105061413A2015-11-18
CN105061197A2015-11-18
CN105777849A2016-07-20
CN105820144A2016-08-03
CN103396368A2013-11-20
CN103191103A2013-07-10
CN102802622A2012-11-28
Other References:
PANG XIAOBIN ET AL.: "Protective effect of mailuoning injection on cerebral Ischemia/Reperfusion Injury in Rats and its mechanism", CHINA JOURNAL OF CHINESE MATERIA MEDICA, 28 February 2014 (2014-02-28), pages 721 - 725
SURUP, FRANK ET AL.: "Sporothriolide derivatives as chemotaxonomic markers for Hypoxylon monticulosum", MYCOLOGY, vol. 5, no. 3, 3 July 2014 (2014-07-03) - 31 December 2014 (2014-12-31), pages 110 - 119, XP055600960, ISSN: 2150-1203, DOI: 10.1080/21501203.2014.929600
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