Title:
CHOLINE ESTER-CONTAINING COMPOSITION FOR ORAL INGESTION
Document Type and Number:
WIPO Patent Application WO/2018/070545
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a composition that contains a choline ester such as acetylcholine as an active ingredient, can be orally ingested by humans by a simple method, and has a blood pressure-lowering effect and/or anti-stress effect. The present invention also addresses the problem of providing: a novel orally-ingestible composition that enables humans to ingest a choline ester such as acetylcholine in a simple method and has a blood pressure-lowering effect and a vasodilating effect; and food products that provide useful supply sources for such a composition.
Inventors:
NAKAMURA KOZO (JP)
Application Number:
PCT/JP2017/037389
Publication Date:
April 19, 2018
Filing Date:
October 16, 2017
Export Citation:
Assignee:
UNIV SHINSHU (JP)
International Classes:
A61K31/221; A23L33/105; A61K9/08; A61K9/19; A61K36/81; A61K36/899; A61K47/12; A61P9/12
Domestic Patent References:
| WO2015147251A1 | 2015-10-01 |
Other References:
HORIUCHI, Y. ET AL.: "Evolutional study on acetylcholine expression", LIFE SCIENCES, vol. 72, no. 15, 28 February 2003 (2003-02-28), pages 1745 - 1756, XP055604279, ISSN: 0024-3205, DOI: 10.1016/S0024-3205(02)02478-5
WATABE AKIRA ET AL.: "Effect of suppressing increase in blood pressure by repetitive oral administration of acetylcholine to spontaneously hypertensive rat", THE 177TH REGULAR MEETING OF THE CENTRAL BRANCH OF JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY AND AGROCHEMISTRY, 24 September 2016 (2016-09-24), pages 22 - 36, XP055604287, Retrieved from the Internet [retrieved on 20171110]
MOMONOKI YOSHIE: "Role of Acetylcholine in plants", CHEMICAL REGULATION OF PLANTS, vol. 30, no. 1, 1995, pages 49 - 61, ISSN: 0388-9130
FLUCK, R. A. ET AL.: "Cholinesterases from plant tissues VI. Preliminary characterization of enzymes from Solanum melongena L. and Zea mays L.", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 410, no. 1, 1975, pages 130 - 134, XP023798181, ISSN: 0006-3002, DOI: doi:10.1016/0005-2744(75)90213-2
NAKAI KENGO ET AL.: "Section of Acetylcholine", 1ST EDITION , 5TH PRINT- PHARMACOLOGY, 1982, pages 139 - 140
IKARASHI, Y. ET AL.: "Study of the Use of the Microwave Magnetic Field for the Rapid Inactivation of Brain Enzymes", THE JAPANESE JOURNAL OF PHARMACOLOGY, vol. 35, no. 4, August 1984 (1984-08-01), pages 371 - 387, XP055604301, ISSN: 1347-3506, DOI: 10.1254/jjp.35.371
KYORITSU SHUPPAN CO. LTD.: "Section of Acetylcholine", CHEMISTRY DICTIONNARY 1- THE 39TH COMPRESSED PRINT, 1987, pages 107
WATABE AKIRA ET AL.: "Effect of suppressing increase in blood pressure by repetitive oral administration of acetylcholine to spontaneously hypertensive rat", THE 177TH REGULAR MEETING OF THE CENTRAL BRANCH OF JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY AND AGROCHEMISTRY, 24 September 2016 (2016-09-24), pages 22 - 36, XP055604287, Retrieved from the Internet
MOMONOKI YOSHIE: "Role of Acetylcholine in plants", CHEMICAL REGULATION OF PLANTS, vol. 30, no. 1, 1995, pages 49 - 61, ISSN: 0388-9130
FLUCK, R. A. ET AL.: "Cholinesterases from plant tissues VI. Preliminary characterization of enzymes from Solanum melongena L. and Zea mays L.", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 410, no. 1, 1975, pages 130 - 134, XP023798181, ISSN: 0006-3002, DOI: doi:10.1016/0005-2744(75)90213-2
NAKAI KENGO ET AL.: "Section of Acetylcholine", 1ST EDITION , 5TH PRINT- PHARMACOLOGY, 1982, pages 139 - 140
IKARASHI, Y. ET AL.: "Study of the Use of the Microwave Magnetic Field for the Rapid Inactivation of Brain Enzymes", THE JAPANESE JOURNAL OF PHARMACOLOGY, vol. 35, no. 4, August 1984 (1984-08-01), pages 371 - 387, XP055604301, ISSN: 1347-3506, DOI: 10.1254/jjp.35.371
KYORITSU SHUPPAN CO. LTD.: "Section of Acetylcholine", CHEMISTRY DICTIONNARY 1- THE 39TH COMPRESSED PRINT, 1987, pages 107
Attorney, Agent or Firm:
KUZUWA, Kiyoshi (JP)
Download PDF: