Title:
CHOLINESTERASE INHIBITOR POLYMORPH AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/156360
Kind Code:
A1
Abstract:
A cholinesterase inhibitor polymorph, wherein specifically disclosed are a succinic octahydroacridine polymorph, a corresponding crystal composition and pharmaceutical composition, and applications thereof. The compound succinic octahydroacridine is used for screening and studying polymorphs, and the discovered polymorphs are appraised and evaluated; crystal forms having better physical and chemical properties are determined for subsequent development and study, and crystal forms having good stability and an excellent therapeutic effect are obtained.
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Inventors:
WANG TONGHUI (CN)
ZHANG JU (CN)
WANG LIHUA (CN)
WANG DEPU (CN)
ZHANG YAXIN (CN)
YU QINGHUA (CN)
ZHANG QI (CN)
LI MINGZE (CN)
ZHANG JU (CN)
WANG LIHUA (CN)
WANG DEPU (CN)
ZHANG YAXIN (CN)
YU QINGHUA (CN)
ZHANG QI (CN)
LI MINGZE (CN)
Application Number:
PCT/CN2020/073389
Publication Date:
August 06, 2020
Filing Date:
January 21, 2020
Export Citation:
Assignee:
CHANGCHUN HUAYUAN HIGH-SCIENCE AND TECH CO LTD (CN)
JIANGSU SHENERYANG HIGH-SCIENCE AND TECH CO LTD (CN)
JIANGSU SHENERYANG HIGH-SCIENCE AND TECH CO LTD (CN)
International Classes:
C07D219/10; A61K31/473; A61P21/00; A61P21/04; A61P25/00; A61P25/18; A61P25/28; C07C51/43; C07C55/10
Domestic Patent References:
| WO2002079166A1 | 2002-10-10 |
Foreign References:
| CN1523016A | 2004-08-25 | |||
| CN109734663A | 2019-05-10 | |||
| CN109651248A | 2019-04-19 | |||
| CN110683987A | 2020-01-14 | |||
| CN109796405A | 2019-05-24 | |||
| CN1523016A | 2004-08-25 |
Other References:
XIA ZHAO, YAN LIANG, JUNYU XU, DONGMEI ZHANG, DEPU WANG, JINGKAI GU, YIMIN CUI: "A single-center, randomized, open-label, dose-escalation study to evaluate the pharmacokinetics of tacrine analogue octahydrogenacridine succinate tablets in healthy Chinese subjects", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 35, no. 9, 31 December 2012 (2012-12-31), pages 1502 - 1508, XP055724299, ISSN: 0918-6158, DOI: 10.1248/bpb.b1200242
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO., pages: 1288 - 1300
"Handbook of Pharmaceutical Excipients", 1986, AMERICAN PHARMACEUTICAL ASSOCIATION & THE PHARMACEUTICAL SOCIETY OF GREAT BRITAIN, pages: 81 - 90
S. BYRN ET AL., PHARMACEUTICAL SOLIDS: A STRATEGIC APPROACH TO REGULATORY CONSIDERATIONS, PHARMACEUTICAL RESEARCH, vol. 12, no. 7, 1995, pages 945 - 954
J. K. HALEBLIANW. MCCRONE: "Pharmaceutical Applications of Polymorphism", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 58, no. 8, 1969, pages 911 - 929
CONG WEI-HONGLIU JIAN-XUN: "Progress in the study of animal models of Alzheimer's disease", CHINESE PHARMACOLOGICAL BULLETIN, vol. 19, no. 5, 2003, pages 497 - 501
SHEN YU-XIANYANG JUNWEI WEI ET AL.: "Learning and memory dysfunction in rats induced by beta-amyloid peptide fragment 25-35", CHINESE PHARMACOLOGICAL BULLETIN, vol. 17, no. 1, 2001, pages 26 - 19
LIN YUCHEN JUNPAOXU BIN ET AL.: "Study of rats with beta-amyloid injection into hippocampus to establish a memory impairment model", CHIN J PSYCHIATRY, vol. 33, no. 4, 2000, pages 222 - 225
ZHAO XIAN-LINFANG XIU-BINLI DONG-PEI: "Establishment of Vascular Dementia Model in Rats", J CHIN MED UNIV, vol. 31, no. 3, 2002, pages 166 - 168
WANG YONG-YANZHANG BO-LI: "Modern Chinese Medicine Clinic and Research on Vascular Dementia", vol. 214, October 2003, PEOPLE'S MEDICAL PUBLISHING HOUSE, article "Editor-in-chief"
See also references of EP 3912971A4
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO., pages: 1288 - 1300
"Handbook of Pharmaceutical Excipients", 1986, AMERICAN PHARMACEUTICAL ASSOCIATION & THE PHARMACEUTICAL SOCIETY OF GREAT BRITAIN, pages: 81 - 90
S. BYRN ET AL., PHARMACEUTICAL SOLIDS: A STRATEGIC APPROACH TO REGULATORY CONSIDERATIONS, PHARMACEUTICAL RESEARCH, vol. 12, no. 7, 1995, pages 945 - 954
J. K. HALEBLIANW. MCCRONE: "Pharmaceutical Applications of Polymorphism", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 58, no. 8, 1969, pages 911 - 929
CONG WEI-HONGLIU JIAN-XUN: "Progress in the study of animal models of Alzheimer's disease", CHINESE PHARMACOLOGICAL BULLETIN, vol. 19, no. 5, 2003, pages 497 - 501
SHEN YU-XIANYANG JUNWEI WEI ET AL.: "Learning and memory dysfunction in rats induced by beta-amyloid peptide fragment 25-35", CHINESE PHARMACOLOGICAL BULLETIN, vol. 17, no. 1, 2001, pages 26 - 19
LIN YUCHEN JUNPAOXU BIN ET AL.: "Study of rats with beta-amyloid injection into hippocampus to establish a memory impairment model", CHIN J PSYCHIATRY, vol. 33, no. 4, 2000, pages 222 - 225
ZHAO XIAN-LINFANG XIU-BINLI DONG-PEI: "Establishment of Vascular Dementia Model in Rats", J CHIN MED UNIV, vol. 31, no. 3, 2002, pages 166 - 168
WANG YONG-YANZHANG BO-LI: "Modern Chinese Medicine Clinic and Research on Vascular Dementia", vol. 214, October 2003, PEOPLE'S MEDICAL PUBLISHING HOUSE, article "Editor-in-chief"
See also references of EP 3912971A4
Attorney, Agent or Firm:
BEIJING GEYUN INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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