"CHOLVACOR" - A MEDICATION IN THE FORM OF LIQUID USED FOR REGULATION OF LD?D3 EXCHANGE

The utility model relates to medicine, in particular, to medications, aimed to normalize blood cholesterol level and might be used as medical treatment and prevention for cardiovascular pathology associated with atherosclerotic change of vascular walls (hypertensive disease, cerebrovascular accident, infarct).

As far as is known, lipid storage disorders cause supply of extra amount of cholesterol to the body, resulting in cholesterol deposit, in particulary endarterial plaque. Cholesterol deposit on vascular walls leads to vascular occlusion that results in increasing of arterial pressure, risk of erebrovascular accident, infarct.

Cholesterol is required by the body to keep itself developing properly, but only in a definite concentration.

Cholesterol is mainly manufactured in the liver and comes to the body from food. At most the reason for high cholesterol level is excess of this substance in the body and its slow excreting, which is caused by taking of foods that are rich in fats containing saturated fatty acids.

Diet therapy is one of the ways to fight high cholesterol level. The basic principles of diet therapy is to decrease intake of fats. Sometimes this way does not reduce high cholesterol sufficiently, so it is time to consider other solution in a form of medications.

There are many different cholesterol lowering medications available to regulate lipid exchange in the body.

"LITOCHOL" [1] is the known medication, which is used as supporting therapy and as a stabilizer of the metabolic disorder caused by high blood cholesterol. The medication is presented in the form of two tablets, one of which contains medicinal plants and target additives as active ingredients and the other one includes lecithin choline, chenodeoxycholic acid, deoxycholic acid, reduced L-glutathione as active ingredients along with other active substances and target additives.

The disadvantage of this medication lays in complexity of its preparation, high

production costs and it is inconvenient from patients' point of view, as they have to take two different tablets. Besides, the medication can cause allergic reactions.

There is another medication [2] known, and this might be also used for blood cholesterol lowering. This medication contains plan raw material, fructose or sorbitol. But low therapy effect is disadvantageous here, along with the possibility of allergic reactions.

One more available medication [3] aims at medical treatment of diabetes and at lowering of high cholesterol, the medication is based on exenatide and dalargin. The disadvantages of this medication include an inconvenience in use, as the medication is given by injection, complexity of preparation, since it is necessary to dissolve components in solvent first and mix them up in required doses then, which is extremely difficult to do at home. Moreover, allergic reactions to the medication may occur.

A further medication [4] that is known lowers blood cholesterol, and is based on β-lactam derivatives containing C-glycosidic fragment in conjunction with inhibitors of cholesterol biosynthesis in molecules or fibrates used for cholesterol reducing. The disadvantage of this medication is that it is quite difficult to get in the right dose, as the dose depends on mixture activity to be delivered to a body, specifically on patient's weight, age, state of health and so on, as a result there is a risk of overdose. The other disadvantage is that the medication is required to be given many times a day. In such a way the treatment with this medication should be provided only under the care of a doctor.

The general disadvantages of the listed-above prior art can therefore be summed up as their relatively high costs, which is crucial, taking into account that these medications should be taken constantly to support a body in more stable state and possible side effects.

The closest medication to the claimed technical solution is considered to be a medication [5] aimed at regulatuion o. ^? lipid exchange and obtained mainly from homeopathic technology .by, multiple sequential diluting and external influence, with substance dose in activated form being significantly small. Moreover the medication contains quite small doses of monoclonal, polyclonal immune or natural antibodies in

activated form as ingredients in regard to substance, these are mainly protein or peptide, which participate in carbohydrate and fat metabolism or regulate said types of metabolism. This medication improves carbohydrate and fat metabolism, is lower in terms of costs and causes minimal side effects. However the production cost of the medication is not low enough, because obtaining of such ingredients as monoclonal, polyclonal immune or natural antibodies in activated form in regard to substance, which are mainly protein or peptide that participate in carbohydrate and fat metabolism, is quite complex process, where particularities of a definite disease should be taken into consideration.

The utility model seeks to develop the medication that by using of activated forms of carbohydrate will provide high therapy effect, require much lower production costs, will be easy-in-use while excluding side effects.

To accomplish all the assigned tasks in the known medication, presented in the form of liquid, aimed at regulation of lipid exchange and principally obtained from homeopathic technology by multiple sequential diluting and external influence, carbohydrates are used as substance and the received liquid additionally contains 20-26 mass % of ethanol in accordance with the utility model.

Monosaccharides are preferably used as carbohydrates in the medication.

Besides, glucose and/or fructose, and/or galactose, and/or mannose are used as monosaccharides .

Experimentally it was determined that the suggested medication, which is obtained from homeopathic technology by multiple sequential diluting and external influence and which contains significantly small doses of carbohydrates in activated form, cleaves cholesterol, triglycerides, effectively lowers indicators of metabolic syndrome, improves lipid exchange and produces curative effect on physiological processes, particularly ensures physiological weight loss, that in general defines therapy effect of the claimed medication by forestalling atherosclerotic diseases.

Placing of ethanol in liquid prepared by homeopathic technology additionally

contributes to cholesterol cleavage. Optimum ethanol amount is defined experimentally and it equals to 20-26 mass %.

Moreover the medication is characterized by specific pharmacological activity, high efficiency, full absence of side effects, ecological cleanness and low production costs.

No side effects are caused due to significantly small doses of carbohydrate substance in the medication formula.

Therapy effect is achieved by taking of minimal amount of the medication, for example, from one to three drops sublingualis besides, the medication doesn't require any special conditions and can be taken by patients on their own. That means that the medication is easy-in-use and besides it causes no risk of overdose.

In summary the medication has high therapy effect, low production costs, no side effects and easy-in-use.

The utility model is realized as follows.

Carbohydrate substance in activated form is diluted sequentially and many times and then is subjected to external, as a rule, mechanical influence, to get significantly small doses thereof, for example, well-known homeopathic technology of potentiation is followed.

With that even reducing of concentration is conducted by sequential diluting of one initial part of substance in nine (on D decimal dilution scale) or in 99 parts (on C centesimal dilution scale) of neutral solvent, then each received composition should be succussed (shaken) vertically for many times and separate containers for every further composition should be used until the desired dose (potency) is reached.

Reducing of concentration can be realized additionally by ultrasound, electromagnetic or by means of any other physical influence. It is possible to use the mixture of different homeopathic dilutions of the medication to enhance curative effect.

25-35 grams of ethanol are added into 1 :600 dilution to make up to 100 grams of solution.

The medication should be taken as drops, from one to three drops a day, depending on patient's state of health.

The suggested medication was given to many patients as test. Comparative figures obtained during the treatment with a new medication are set in the table.

Table

The experimental tests have been conducted for 120 days. Blood cholesterol lowering, reducing of triglycerides and indicators of metabolic syndrome along with gain in health have been seen in all cases. Besides, physiological weight loss of patients was reported.

So, the conducted experimental tests have proved high therapy effect of the medication.

References cited

1. Patent of Russian Federation No 2292902 C2, pub. 10.02.2007, MPK ⁸ A61P 3/00;

2. Patent of Russian Federation No 2283659 Cl, pub. 20.09.2006, MPK ⁸ A61P 3/12;

3. PCT application for the invention of Russian Federation No 2007101695 A, pub. 27.07.2008, MPK ⁸ A61K38/00;

4. Patent of Russian Federation No 2328307 C2, pub. 27.07.2006, MPK ⁸ A61K 45/06;

5. Patent of Russian Federation No 2199345 Cl, pub. 27.02.2003, MPK ⁷ A61K/395, A61P3/00.