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Title:
CHONDROITIN SYNTHETASE AND NUCLEIC ACID CODING FOR THE ENZYME
Document Type and Number:
WIPO Patent Application WO/2003/102193
Kind Code:
A1
Abstract:
Novel chondroitin synthetase derived from human, which is an enzyme for synthesizing the fundamental skeleton of chondroitin and which exhibits not only glucuronate rearrangement activity but also N-acetylgalactosamine rearrangement activity.

Inventors:
Narimatsu, Hisashi c/o National Institute of Advanced (Industrial Science and Technology AIST Tsukuba Central 2, 1-1, Umezono 1-chom, Tsukuba-shi Ibaraki, 305-8568, JP)
Kimata, Koji (Room 1201, Esupoa-Yashiroguchi 102-1, Yashiroguchi 2-chome, Meito-k, Nagoya-shi Aichi, 465-0013, JP)
Yada, Toshikazu (27-2, Nishiyada-machi Kuwana-shi, Mie, 511-0056, JP)
Sato, Takashi c/o National Institute of Advanced (Industrial Science and Technology AIST Tsukuba Central 2, 1-1, Umezono 1-chom, Tsukuba-shi Ibaraki, 305-8568, JP)
Goto, Masanori c/o National Institute of Advanced (Industrial Science and Technology AIST Tsukuba Central 2, 1-1, Umezono 1-chom, Tsukuba-shi Ibaraki, 305-8568, JP)
Application Number:
PCT/JP2003/006880
Publication Date:
December 11, 2003
Filing Date:
May 30, 2003
Export Citation:
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Assignee:
SEIKAGAKU CORPORATION (1-5 Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo, 103-0023, JP)
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (3-1 Kasumigaseki 1-chome, Chiyoda-ku, Tokyo, 100-8921, JP)
Narimatsu, Hisashi c/o National Institute of Advanced (Industrial Science and Technology AIST Tsukuba Central 2, 1-1, Umezono 1-chom, Tsukuba-shi Ibaraki, 305-8568, JP)
Kimata, Koji (Room 1201, Esupoa-Yashiroguchi 102-1, Yashiroguchi 2-chome, Meito-k, Nagoya-shi Aichi, 465-0013, JP)
Yada, Toshikazu (27-2, Nishiyada-machi Kuwana-shi, Mie, 511-0056, JP)
Sato, Takashi c/o National Institute of Advanced (Industrial Science and Technology AIST Tsukuba Central 2, 1-1, Umezono 1-chom, Tsukuba-shi Ibaraki, 305-8568, JP)
Goto, Masanori c/o National Institute of Advanced (Industrial Science and Technology AIST Tsukuba Central 2, 1-1, Umezono 1-chom, Tsukuba-shi Ibaraki, 305-8568, JP)
International Classes:
C12N1/15; C12N1/19; C12N1/21; C12N9/10; C12N15/00; C12N15/54; (IPC1-7): C12N15/54; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/10; C12P19/04
Domestic Patent References:
WO2001068848A2
WO2000027437A2
WO2001080810A2
Foreign References:
JP2003199583A
Other References:
KITAGAWA H. ET AL.: 'Characterization of serum beta-glucuronyl-transferase involved in chondroitin sulfate biosynthesis' GLYCOBIOLOGY vol. 7, no. 7, 1997, pages 905 - 911, XP002972317
ROHMANN K. ET AL.: 'Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate' EUR. J. BIOCHEM. vol. 148, no. 3, 1985, pages 463 - 469, XP002972318
KITAGAWA H. ET AL.: 'Molecular cloning and expression of a human chondroitin synthase' J. BIOL. CHEM. vol. 276, no. 42, 2001, pages 38721 - 38726, XP002224170
DE ANGELIS P.L. ET AL.: 'Identification and molecular cloning of a chondroitin synthase from pasteurella multocida type F' J. BIOL. CHEM. vol. 275, no. 31, 2000, pages 24124 - 24129, XP002163608
UYAMA T. ET AL.: 'Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate' J. BIOL. CHEM. vol. 277, no. 11, March 2002, pages 8841 - 8846, XP002972319
GOTOH M. ET AL.: 'Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine' J. BIOL. CHEM. vol. 277, no. 41, October 2002, pages 38179 - 38188, XP002972320
GOTOH M. ET AL.: 'Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis' J. BIOL. CHEM. vol. 277, no. 41, October 2002, pages 38189 - 38196, XP002972321
SATO T. ET AL.: 'Differential roles of two N-acetylgalactosaminyltransferase, CSGa1NAcT-1 and a novel enzyme, CSGa1NAcT-2. Initiation and elongation in synthesis of chondroitin sulfate' J. BIOL. CHEM. vol. 278, no. 5, January 2003, pages 3063 - 3071, XP002972322
See also references of EP 1514939A1
Attorney, Agent or Firm:
Oguri, Shohei (Eikoh Patent Office, 28th Floor ARK Mori Building, 12-32, Akasaka 1-chom, Minato-ku Tokyo, 107-6028, JP)
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