Title:
CHORIONIC GONADOTROPIN DNA VACCINES AND METHODS
Document Type and Number:
WIPO Patent Application WO2000041717
Kind Code:
A3
Abstract:
The invention relates to immunotherapy of a mammalian subject by exposing the immune response cells of the subject to a nucleic acid construct encoding at least one hCG immunogenic epitope or precursor thereof such that the nucleic acid construct is taken up and processed by the immune response cells. The invention further relates to compositions comprising such hCG-encoding nucleic acid constructs.
Inventors:
IVERSEN PATRICK L
Application Number:
PCT/US1999/030232
Publication Date:
November 16, 2000
Filing Date:
December 17, 1999
Export Citation:
Assignee:
AVI BIOPHARMA INC (US)
International Classes:
C12N15/09; A61K31/7088; A61K38/00; A61K39/00; A61K48/00; A61P35/00; C12N5/10; C12N15/16; (IPC1-7): A61K39/00; C12N15/16; A61P35/00; A61P43/00
Domestic Patent References:
| WO1986007383A1 | 1986-12-18 | |||
| WO1996032932A1 | 1996-10-24 |
Foreign References:
| US5733553A | 1998-03-31 | |||
| US4855285A | 1989-08-08 | |||
| US5762931A | 1998-06-09 |
Other References:
GEISSLER MICHAEL ET AL: "Genetic immunization with the free human chorionic gonadotropin beta subunit elicits cytotoxic T lymphocyte responses and protects against tumor formation in mice.", LABORATORY INVESTIGATION, vol. 76, no. 6, 1997, pages 859 - 871, XP000929755, ISSN: 0023-6837
LAYLOR R ET AL: "Priming for an immune response to human chorionic gonadotropin beta chain using DNA vaccination.", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol. 40, no. 4, October 1998 (1998-10-01), VII International Congress of Reproductive Immunology;New Delhi, India; October 27-30, 1998, pages 269, XP000929769, ISSN: 1046-7408
DIRNHOFER S ET AL: "THE MOLECULAR BASIS FOR EPITOPES ON THE FREE BETA-SUBUNIT OF HUMAN CHORIONIC GONADOTROPHIN (HCG), ITS CARBOXYL-TERMINAL PEPTIDE AND THE HCGBETA-CORE FRAGMENT", JOURNAL OF ENDOCRINOLOGY,GB,BRISTOL, vol. 141, no. 1, 1 April 1994 (1994-04-01), pages 153 - 162, XP000609254, ISSN: 0022-0795
DURRANT L G: "Cancer vaccines.", ANTI-CANCER DRUGS, vol. 8, no. 8, 1997, pages 727 - 733, XP000929776, ISSN: 0959-4973
DE-CHU TANG ET AL: "GENETIC IMMUNIZATION IS A SIMPLE METHOD FOR ELICITING AN IMMUNE RESPONSE", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 356, no. 6365, 12 March 1992 (1992-03-12), pages 152 - 154, XP000310569, ISSN: 0028-0836
LAYLOR R ET AL: "Priming for an immune response to human chorionic gonadotropin beta chain using DNA vaccination.", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol. 40, no. 4, October 1998 (1998-10-01), VII International Congress of Reproductive Immunology;New Delhi, India; October 27-30, 1998, pages 269, XP000929769, ISSN: 1046-7408
DIRNHOFER S ET AL: "THE MOLECULAR BASIS FOR EPITOPES ON THE FREE BETA-SUBUNIT OF HUMAN CHORIONIC GONADOTROPHIN (HCG), ITS CARBOXYL-TERMINAL PEPTIDE AND THE HCGBETA-CORE FRAGMENT", JOURNAL OF ENDOCRINOLOGY,GB,BRISTOL, vol. 141, no. 1, 1 April 1994 (1994-04-01), pages 153 - 162, XP000609254, ISSN: 0022-0795
DURRANT L G: "Cancer vaccines.", ANTI-CANCER DRUGS, vol. 8, no. 8, 1997, pages 727 - 733, XP000929776, ISSN: 0959-4973
DE-CHU TANG ET AL: "GENETIC IMMUNIZATION IS A SIMPLE METHOD FOR ELICITING AN IMMUNE RESPONSE", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 356, no. 6365, 12 March 1992 (1992-03-12), pages 152 - 154, XP000310569, ISSN: 0028-0836
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