Title:
CHROMATOGRAPHIC METHOD FOR COLLECTING BLOOD COAGULATION FACTOR VII WITH HIGH YIELD
Document Type and Number:
WIPO Patent Application WO/2018/117143
Kind Code:
A1
Abstract:
Provided is a chromatographic method for collecting blood coagulation factor VII and/or activated blood coagulation factor VII from a plasma-derived fraction with high yield. According to the method of the present application, it becomes possible to collect the desired blood coagulation factor VII and/or activated blood coagulation factor VII with yield as high as 90% or more by allowing a portion of blood coagulation factor VII and/or activated blood coagulation factor VII, which remains in a non-adsorbed fraction that is not adsorbed onto a first anion exchange resin, to be adsorbed onto a second anion exchange resin.
Inventors:
EBISU KENTARO (JP)
KAI TAKASHI (JP)
MATSUO NOZOMI (JP)
KAI TAKASHI (JP)
MATSUO NOZOMI (JP)
Application Number:
PCT/JP2017/045680
Publication Date:
June 28, 2018
Filing Date:
December 20, 2017
Export Citation:
Assignee:
THE CHEMO SERO THERAPEUTIC RES INSTITUTE (JP)
International Classes:
C07K1/18; A61K38/36; A61P7/04
Domestic Patent References:
| WO2015136217A1 | 2015-09-17 |
Foreign References:
| JPH1059866A | 1998-03-03 | |||
| JPH08508264A | 1996-09-03 | |||
| JP2008275423A | 2008-11-13 | |||
| JP2016109468A | 2016-06-20 | |||
| JPH03155797A | 1991-07-03 | |||
| JP2824430B2 | 1998-11-11 | |||
| JP2002518411A | 2002-06-25 |
Other References:
TOMOKIYO, K. ET AL.: "Large-scale production and properties of human plasma-derived activated Factor VII concentrate", VOX SANGUINIS, vol. 84, no. 1, 1 January 2003 (2003-01-01), pages 54 - 64, XP002286502, ISSN: 0042-9007, DOI: 10.1046/j.1423-0410.2003.00247.x
HEDNER ET AL., J.CLIN.INVEST., vol. 71, 1983, pages 1836
PETER,W. ET AL., BLOOD, vol. 80, 1992, pages 25 - 28
PRYDZ, J.SCAND.J., CLIN.LAB.INVEST., vol. 1, 1964, pages 101
GLADHAUG, A. ET AL., BIOCHIM.BIOPHYS.ACTA, 1970, pages 105
LAAKE,K. ET AL., THROMB.RES., vol. 5, 1974, pages 539
SCHIFFMAN, S. ET AL., THRCMB RES., vol. 6, 1975, pages 273
OSTERUD,3. ET AL., PROC.NATL.ACAD.SCI.U.S.A., vol. 74, 1977, pages 5260
BROZE,JR.G.J. ET AL., J.BIOL.CHEM., vol. 255, 1980, pages 1242
TOMOKIYO ET AL., VOX SANGUINI, vol. 84, 2003, pages 54 - 64
"PRODUCTION OF PLASMA PROTEINS FOR THERAPEUTIC USE", 2013, JOHN WILEY & SONS, INC., pages: 68
See also references of EP 3560946A4
HEDNER ET AL., J.CLIN.INVEST., vol. 71, 1983, pages 1836
PETER,W. ET AL., BLOOD, vol. 80, 1992, pages 25 - 28
PRYDZ, J.SCAND.J., CLIN.LAB.INVEST., vol. 1, 1964, pages 101
GLADHAUG, A. ET AL., BIOCHIM.BIOPHYS.ACTA, 1970, pages 105
LAAKE,K. ET AL., THROMB.RES., vol. 5, 1974, pages 539
SCHIFFMAN, S. ET AL., THRCMB RES., vol. 6, 1975, pages 273
OSTERUD,3. ET AL., PROC.NATL.ACAD.SCI.U.S.A., vol. 74, 1977, pages 5260
BROZE,JR.G.J. ET AL., J.BIOL.CHEM., vol. 255, 1980, pages 1242
TOMOKIYO ET AL., VOX SANGUINI, vol. 84, 2003, pages 54 - 64
"PRODUCTION OF PLASMA PROTEINS FOR THERAPEUTIC USE", 2013, JOHN WILEY & SONS, INC., pages: 68
See also references of EP 3560946A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Download PDF:
Previous Patent: BIRD-REPELLENT COATING MATERIAL
Next Patent: FIELD-WINDING TYPE ROTATING ELECTRIC MACHINE
Next Patent: FIELD-WINDING TYPE ROTATING ELECTRIC MACHINE