CHROMATOGRAPHY MEDIA AND METHOD - EMD MILLIPORE CORP

Title:

CHROMATOGRAPHY MEDIA AND METHOD

Document Type and Number:

WIPO Patent Application WO/2012/015908

Kind Code:

A3

Abstract:

Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).

Inventors:

YAVORSKY DAVID (US)
AMARA JOHN (US)
UMANA JOAQUIN (US)
CATALDO WILLIAM (US)
KOZLOV MIKHAIL (US)
STONE MATTHEW (US)

Application Number:

PCT/US2011/045519

Publication Date:

May 31, 2012

Filing Date:

July 27, 2011

Export Citation:

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Assignee:

EMD MILLIPORE CORP (US)
YAVORSKY DAVID (US)
AMARA JOHN (US)
UMANA JOAQUIN (US)
CATALDO WILLIAM (US)
KOZLOV MIKHAIL (US)
STONE MATTHEW (US)

International Classes:

B01D15/36; B01J20/28; B01J20/285; C07K1/18

Foreign References:

US6736973B1	2004-05-18
US4169790A	1979-10-02
US20080105612A1	2008-05-08
US20060032816A1	2006-02-16
US7291263B2	2007-11-06
US5468847A	1995-11-21

Other References: