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Title:
REMEDIES/PREVENTIVES FOR CHRONIC SKIN DISEASE
Document Type and Number:
WIPO Patent Application WO/2006/041121
Kind Code:
A1
Abstract:
It is intended to provide: a remedy and/or a preventive for a chronic skin disease which comprises, as the active ingredients, (a) a phosphodiesterase (PDE)-IV inhibitor or a pharmacologically acceptable salt thereof and (b) a steroid drug; a remedy and/or a preventive for a chronic skin disease for administering the following active ingredients, either simultaneously or separately at an interval, (a) a PDE-IV inhibitor or a pharmacologically acceptable salt thereof and (b) a steroid drug; a kit for treating and/or preventing a chronic skin disease characterized by comprising (a) a first component containing a PDE-IV inhibitor or a pharmacologically acceptable salt thereof and (b) a second component containing a steroid drug, and so on.

Inventors:
Harada, Daisuke
Kobayashi, Katsuya
Manabe, Haruhiko
Ohshima, Etsuo
Application Number:
PCT/JP2005/018855
Publication Date:
April 20, 2006
Filing Date:
October 13, 2005
Export Citation:
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Assignee:
KYOWA HAKKO KOGYO CO., LTD. (6-1 Ohtemachi 1-chome, Chiyoda-ku, Tokyo 85, 10081, JP)
Harada, Daisuke
Kobayashi, Katsuya
Manabe, Haruhiko
Ohshima, Etsuo
International Classes:
A61K45/06; A61K31/277; A61K31/357; A61K31/4409; A61K31/4427; A61K31/443; A61K31/4433; A61K31/496; A61K31/573; A61K31/58; A61P17/00; A61P17/04; A61P17/06; A61P29/00; A61P37/08; A61P43/00; C07D213/30; C07D213/75; C07D405/06; C07D405/12; C07J5/00; C07J7/00; C07J71/00
Domestic Patent References:
WO2001019373A2
WO2004058729A1
WO1996036624A1
WO1999016768A1
WO2000014085A1
WO2005049581A1
Foreign References:
JP2002504091A
JPH08512041A
JPH07504442A
JP2002513017A
JPH06507405A
JP2003513028A
Other References:
ASHTON MJ ET AL: 'Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogues.' J MED CHEM. vol. 37, 1994, pages 1696 - 1703, XP002015726
CHRISTENSEN SB ET AL: '1,4-Cyclohexanecarboxylates: Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma.' J MED CHEM. vol. 41, 1998, pages 821 - 835, XP002173934
DUPLANTIER AJ ET AL: '7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c √úpyridines as Novel Inhibitors of Human Eosinophil Phosphodiesterase.' J MED CHEM. vol. 41, 1998, pages 2268 - 2277, XP002938447
BAUMER W ET AL: 'AWD 12-281, a highly selective phosphodiesterase 4 inhibitor, is effective in the prevention and treatment of inflammatory reactions in a model of allergic dermatitis.' J PHARM PHARMACOL. vol. 55, 2003, pages 1107 - 1114, XP009019412
BAUMER W ET AL: 'Effects of the phosphodiesterase 4 inhibitors SB 207499 and AWD 12-281 on the inflammatory reaction in a model of allergic dermatitis.' EUR J PHARMACOL. vol. 446, 2002, pages 195 - 200, XP002258973
GRIFFITHS C E M ET AL: 'Randomized comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis.' BR J DERMATOL. vol. 147, 2002, pages 299 - 307, XP002994971
HANIFIN JM ET AL: 'Biochemical and immunologic mechanisms in atopic dermatitis: New targets for emerging therapies.' J AM ACAD DERMATOL. vol. 41, 1999, pages 72 - 77, XP008008916
DOHERTY AM ET AL: 'Phosphodiesterase 4 inhibitors as novel anti-inflammatory agents.' CURR OPIN CHEM BIOL. vol. 3, 1999, pages 466 - 473, XP002994972
GRISWOLD D E ET AL: 'SB 207499 (Ariflo), a Second Generation Phosphodiesterase 4 Inhibitor, Reduces Tumor Necrosis Factor Alpha and Interleukin-4 Production in Vivo.' J PHARMACOL EXP THER. vol. 287, no. 2, 1998, pages 705 - 711, XP001121243
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