Title:
CINNAMIC AMIDE DERIVATIVE HAVING FXR ACTIVATING EFFECT, PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/085991
Kind Code:
A1
Abstract:
The present disclosure pertains to a cinnamic amide derivative activating an FXR function, a pharmaceutical composition comprising an isomer, solvate, or pharmaceutically acceptable salt thereof, and a preparation method therefor.
Inventors:
KWAK JAE-HWAN (KR)
JUNG YOUNG-SUK (KR)
KWON DOYOUNG (KR)
KIM MIN WOO (KR)
KIM SOU HYUN (KR)
JUNG YOUNG-SUK (KR)
KWON DOYOUNG (KR)
KIM MIN WOO (KR)
KIM SOU HYUN (KR)
Application Number:
PCT/KR2020/014763
Publication Date:
May 06, 2021
Filing Date:
October 28, 2020
Export Citation:
Assignee:
KYUNGSUNG UNIV INDUSTRY COOPERATION FOUNDATION (KR)
NAT UNIV PUSAN IND UNIV COOP FOUND (KR)
NAT UNIV PUSAN IND UNIV COOP FOUND (KR)
International Classes:
C07C235/34; A61K31/198; A61K31/223; A61K31/42; A61P3/00; C07C231/22; C07D261/06
Foreign References:
| US4981680A | 1991-01-01 | |||
| CN101255124A | 2008-09-03 | |||
| EP0407200B1 | 1994-06-01 |
Other References:
MAYA SPASOVA, VESSELA KORTENSKA-KANCHEVA, ISKRA TOTSEVA, GALYA IVANOVA, LYUBOMIR GEORGIEV, TSENKA MILKOVA: "Synthesis of cinnamoyl and hydroxycinnamoyl amino acidconjugates and evaluation of their antioxidant activity.", JOURNAL OF PEPTIDE SCIENCE, vol. 12, 1 May 2006 (2006-05-01), pages 369 - 375, XP055809008, DOI: 10.1002/psc.736
CHOCHKOVA MAYA G., PETROVA PETRANKA P., STOYKOVA BOYKA M., IVANOVA GALYA I., ŠTÍCHA MARTIN, DIBÓ GÁBOR, MILKOVA TSENKA S.: "Structure-Activity Relationships of N -Cinnamoyl and Hydroxycinnamoyl Amides on α -Glucosidase Inhibition", JOURNAL OF CHEMISTRY, HINDAWI PUBLISHING CORPORATION, US, vol. 2017, 1 January 2017 (2017-01-01), US, pages 1 - 5, XP055809009, ISSN: 2090-9063, DOI: 10.1155/2017/6080129
Y. ZHANG, F. Y. LEE, G. BARRERA, H. LEE, C. VALES, F. J. GONZALEZ, T. M. WILLSON, P. A. EDWARDS: "Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 103, no. 4, 24 January 2006 (2006-01-24), pages 1006 - 1011, XP055511748, ISSN: 0027-8424, DOI: 10.1073/pnas.0506982103
CHOCHKOVA MAYA G., PETROVA PETRANKA P., STOYKOVA BOYKA M., IVANOVA GALYA I., ŠTÍCHA MARTIN, DIBÓ GÁBOR, MILKOVA TSENKA S.: "Structure-Activity Relationships of N -Cinnamoyl and Hydroxycinnamoyl Amides on α -Glucosidase Inhibition", JOURNAL OF CHEMISTRY, HINDAWI PUBLISHING CORPORATION, US, vol. 2017, 1 January 2017 (2017-01-01), US, pages 1 - 5, XP055809009, ISSN: 2090-9063, DOI: 10.1155/2017/6080129
Y. ZHANG, F. Y. LEE, G. BARRERA, H. LEE, C. VALES, F. J. GONZALEZ, T. M. WILLSON, P. A. EDWARDS: "Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 103, no. 4, 24 January 2006 (2006-01-24), pages 1006 - 1011, XP055511748, ISSN: 0027-8424, DOI: 10.1073/pnas.0506982103
Attorney, Agent or Firm:
DODAM IP LAW FIRM (KR)
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