Title:
CINNAMOMUM BURMANNII MONOTERPENE SYNTHASE CBTPS1, RELATED BIOMATERIAL THEREOF AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/088914
Kind Code:
A1
Abstract:
Provided are a cinnamomum burmannii monoterpene synthase CbTPS1, an amino acid sequence thereof, a nucleic acid molecule encoding the protein, an application thereof in preparing the monoterpene synthase, and a method for preparing d-borneol from the monoterpene synthase.
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Inventors:
HUANG LUQI (CN)
SU PING (CN)
MA RUI (CN)
CUI GUANGHONG (CN)
GUO JUAN (CN)
JIN BAOLONG (CN)
HU YATING (CN)
BAO JICHEN (CN)
SU PING (CN)
MA RUI (CN)
CUI GUANGHONG (CN)
GUO JUAN (CN)
JIN BAOLONG (CN)
HU YATING (CN)
BAO JICHEN (CN)
Application Number:
PCT/CN2020/126683
Publication Date:
May 14, 2021
Filing Date:
November 05, 2020
Export Citation:
Assignee:
SICHUAN HONGDA PHARMACEUTICAL CO LTD (CN)
International Classes:
C12N9/88; C12N15/60; C12N15/70; C12P9/00; C12R1/865
Domestic Patent References:
| WO2001007565A2 | 2001-02-01 |
Foreign References:
| CN108395997A | 2018-08-14 | |||
| CN105002194A | 2015-10-28 | |||
| CN107002062A | 2017-08-01 | |||
| CN108893482A | 2018-11-27 | |||
| CN107630025A | 2018-01-26 |
Other References:
BORGHI MONICA; XIE DE-YU: "Cloning and characterization of a monoterpene synthase gene from flowers ofCamelina sativa", PLANTA, SPRINGER VERLAG., DE, vol. 247, no. 2, 26 October 2017 (2017-10-26), DE, pages 443 - 457, XP036392462, ISSN: 0032-0935, DOI: 10.1007/s00425-017-2801-x
DATABASE NUCLEOTIDE 15 April 2005 (2005-04-15), ANONYMOUS: "Cinnamomum tenuipilum mRNA for geraniol synthase (GerS gene)", XP055810606, retrieved from NCBI Database accession no. AJ457070
WANG SZHANG DHU J ET AL.: "A clinical and mechanistic study of topical borneol-induced analgesia [J", EMBO MOLECULAR MEDICINE, vol. 9, no. 6, 2017, pages 802 - 815
TANG SWANG AYAN X ET AL.: "Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson's disease [J", DRUG DELIV, vol. 26, no. 1, 2019, pages 700 - 707
YU BZHONG FMYAO Y ET AL.: "Synergistic protection of tetramethylpyrazine phosphate and borneol on brain microvascular endothelium cells injured by hypoxia [J", AM J TRANSL RES., vol. 11, no. 4, 2019, pages 2168 - 2180
SHI S, WU Q, SU J, BORNEOL IN CHINA [J]. JOURNAL OF ESSENTIAL OIL RESEARCH, vol. 25, no. 5, 2013, pages 7
CHEN FTHOLL DBOHLMANN J ET AL.: "The family of terpene synthases in plants: a mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom [J", THE PLANT JOURNAL: FOR CELL AND MOLECULAR BIOLOGY, vol. 66, no. 1, 2011, pages 212 - 229, XP002738986, DOI: 10.1111/j.1365-313X.2011.04520.x
TRAPP SCCROTEAU R: "Genomic organization of plant terpene synthases and molecular evolutionary implications [J", GENETICS, vol. 158, 2001, pages 811 - 832, XP002282505
YANG ZAN WLIU S ET AL.: "Mining of candidate genes involved in the biosynthesis of dextrorotatory borneol in Cinnamomum burmannii by transcriptomic analysis on three chemotypes[J", PEERJ, vol. 8, no. 4, 2020, pages e9311
CAS , no. 464-43-7
See also references of EP 4056699A4
DATABASE NUCLEOTIDE 15 April 2005 (2005-04-15), ANONYMOUS: "Cinnamomum tenuipilum mRNA for geraniol synthase (GerS gene)", XP055810606, retrieved from NCBI Database accession no. AJ457070
WANG SZHANG DHU J ET AL.: "A clinical and mechanistic study of topical borneol-induced analgesia [J", EMBO MOLECULAR MEDICINE, vol. 9, no. 6, 2017, pages 802 - 815
TANG SWANG AYAN X ET AL.: "Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson's disease [J", DRUG DELIV, vol. 26, no. 1, 2019, pages 700 - 707
YU BZHONG FMYAO Y ET AL.: "Synergistic protection of tetramethylpyrazine phosphate and borneol on brain microvascular endothelium cells injured by hypoxia [J", AM J TRANSL RES., vol. 11, no. 4, 2019, pages 2168 - 2180
SHI S, WU Q, SU J, BORNEOL IN CHINA [J]. JOURNAL OF ESSENTIAL OIL RESEARCH, vol. 25, no. 5, 2013, pages 7
CHEN FTHOLL DBOHLMANN J ET AL.: "The family of terpene synthases in plants: a mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom [J", THE PLANT JOURNAL: FOR CELL AND MOLECULAR BIOLOGY, vol. 66, no. 1, 2011, pages 212 - 229, XP002738986, DOI: 10.1111/j.1365-313X.2011.04520.x
TRAPP SCCROTEAU R: "Genomic organization of plant terpene synthases and molecular evolutionary implications [J", GENETICS, vol. 158, 2001, pages 811 - 832, XP002282505
YANG ZAN WLIU S ET AL.: "Mining of candidate genes involved in the biosynthesis of dextrorotatory borneol in Cinnamomum burmannii by transcriptomic analysis on three chemotypes[J", PEERJ, vol. 8, no. 4, 2020, pages e9311
CAS , no. 464-43-7
See also references of EP 4056699A4
Attorney, Agent or Firm:
JEEKAI&PARTNERS (CN)
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