Title:
CINNAMYL ALCOHOL DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2004/080943
Kind Code:
A1
Abstract:
Compounds represented by the following general formula (I) or salts thereof: (I) wherein each symbol is as defined in the description. Because of having an activity of controlling peroxisome proliferator-activated receptors, the compounds represented by the general formula (I) or salts thereof are useful as hypoglycemic drugs, lipid level-lowering drugs, preventives/remedies for metabolic errors such as diabetes, obesity, metabolic syndrome, hypercholesteremia and hyperlipoproteinemia, hyperlipemia, arteriosclerosis, hypertension, circulatory diseases, hyperphagia, ischemic heart diseases and so on, HDL cholesterol-elevating agents, LDL cholesterol and/or VLDL cholesterol-lowering agents, and drugs for relieving risk factors of diabetes and metabolic syndrome.
Inventors:
KUSUDA SHINYA (JP)
NAKAYAMA YOSHISUKE (JP)
TAJIMA HISAO (JP)
KATO SACHIKO (JP)
NAKAYAMA YOSHISUKE (JP)
TAJIMA HISAO (JP)
KATO SACHIKO (JP)
Application Number:
PCT/JP2004/003112
Publication Date:
September 23, 2004
Filing Date:
March 10, 2004
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
KUSUDA SHINYA (JP)
NAKAYAMA YOSHISUKE (JP)
TAJIMA HISAO (JP)
KATO SACHIKO (JP)
KUSUDA SHINYA (JP)
NAKAYAMA YOSHISUKE (JP)
TAJIMA HISAO (JP)
KATO SACHIKO (JP)
International Classes:
A61K31/192; A61K31/222; A61K31/421; A61K31/4245; A61K31/426; A61K31/428; A61K31/44; A61K31/4409; A61K31/445; A61K31/454; A61K31/4545; A61K31/496; A61K31/5355; A61K31/5377; A61K31/541; C07C51/00; C07C69/734; (IPC1-7): C07C69/616; A61K31/192; A61K31/222; A61K31/421; A61K31/4245; A61K31/426; A61K31/428; A61K31/44; A61K31/4409; A61K31/445; A61K31/454; A61K31/4545; A61K31/496; A61K31/5355; A61K31/5377; A61K31/541; C07C59/66; C07C235/34; C07C255/37; C07C311/51; C07C323/19
Domestic Patent References:
| WO2002098840A1 | 2002-12-12 | |||
| WO2001016120A1 | 2001-03-08 | |||
| WO2004011446A1 | 2004-02-05 | |||
| WO2004022551A1 | 2004-03-18 | |||
| WO1995027692A1 | 1995-10-19 | |||
| WO1998004508A1 | 1998-02-05 | |||
| WO2000037433A1 | 2000-06-29 |
Foreign References:
| US6288261B1 | 2001-09-11 | |||
| US6204293B1 | 2001-03-20 |
Other References:
See also references of EP 1604971A4
Attorney, Agent or Firm:
Ohie, Kunihisa (Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho, 2-chom, Chuo-ku Tokyo, JP)
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