CIRCADIAN RHYTHM REGULATOR - ORYZA OIL & FAT CHEMICAL CO LTD

Title:

CIRCADIAN RHYTHM REGULATOR

Document Type and Number:

WIPO Patent Application WO/2018/138929

Kind Code:

A1

Abstract:

Provided are a novel use of 1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-β-D-glucose (hereinafter abbreviated as "GHG") which is contained in a large amount in purple tea produced in Kenya (scientific name: Camellia sinensis, variety name: TRFK306); and a novel circadian rhythm regulator which is widely usable as medicines, beverages, foods and cosmetics. The circadian rhythm regulator according to the present invention is characterized by comprising GHG as an active ingredient having an effect of promoting the expression of Bmal1 gene. Also, the circadian rhythm regulator according to the present invention is characterized by comprising a GHG-containing extract derived from the purple tea produced in Kenya as an active ingredient having an effect of promoting the expression of Bmal1 gene.

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Inventors:

SHIMODA HIROSHI (JP)
KOHATSU MARINA (JP)
TODA KAZUYA (JP)
MURAI HIROMICHI (JP)

Application Number:

PCT/JP2017/003246

Publication Date:

August 02, 2018

Filing Date:

January 30, 2017

Export Citation:

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Assignee:

ORYZA OIL & FAT CHEMICAL CO LTD (JP)

International Classes:

A61K31/7024; A23L2/38; A23L2/52; A23L33/105; A61K8/60; A61K36/45; A61P3/04; A61P3/10; A61P9/12; A61P17/00; A61P25/20; A61P43/00; A61Q5/00; A61Q19/00

Foreign References:

JP2015157774A	2015-09-03
JP2016175842A	2016-10-06
JP2011182703A	2011-09-22

Other References:

"PURPLE TEA EXTRACT", ORYZA OIL & FAT CHEMICAL CO., LTD., 9 October 2013 (2013-10-09), pages 1 - 32, Retrieved from the Internet [retrieved on 20170313]
LI, H. ET AL.: "Green tea (-)-epigallocatechin- 3-gallate counter-acts daytime overeating induced by high-fat diet in mice", MOLECULAR NUTRITION & FOOD RESEARCH, vol. 60, no. 12, December 2016 (2016-12-01), pages 2565 - 2575, XP055548633

Attorney, Agent or Firm:

KUMAZAKI Yoichi (JP)

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