Title:
CIRCULAR ANTIVIRAL RNA
Document Type and Number:
WIPO Patent Application WO/2013/162350
Kind Code:
A3
Abstract:
The present invention relates to triple helix forming oligonucleotides (TFO) for use in the treatment of diseases mediated by single stranded RNA viruses, for example corona viruses. The invention provides a selection of circular TFO sequences that target different regions of the genome of the virulent Feline coronavirus and that efficiently block the virus' replication. Thereby the TFO of the present invention provide new means for therapy against viral diseases. The invention relates to the novel TFOs, pharmaceutical compositions comprising the same, the new TFO design and their uses in the treatment of viral diseases.
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Inventors:
OMAR ABDUL RAHMAN (MY)
TEJO BIMO A (MY)
TAN SHEAU WEI (MY)
CHOONG OI KUAN (MY)
TEJO BIMO A (MY)
TAN SHEAU WEI (MY)
CHOONG OI KUAN (MY)
Application Number:
PCT/MY2013/000088
Publication Date:
December 19, 2013
Filing Date:
April 23, 2013
Export Citation:
Assignee:
UNIV PUTRA MALAYSIA (MY)
International Classes:
C12N15/11; A61K48/00; A61P31/14
Foreign References:
| US20030148985A1 | 2003-08-07 |
Other References:
YE, ZHAOYANG ET AL.: "Sequence-specific triple helix formation with genomic DNA", BIOCHEMISTRY, vol. 46, no. 40, 11 September 2007 (2007-09-11), pages 11240 - 11252
MACRIS, MARGARET A. ET AL.: "Transcription dependence of chromosome gene targeting by triplex-forming oligonucleotides", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 5, 31 January 2003 (2003-01-31), pages 3357 - 3362
SIMON, PHILIPPE ET AL.: "Targeting DNA with triplex-forming oligonucleotides to modify gene sequence", BIOCHIMIE, vol. 90, no. ISSUE, 2008, pages 1109 - 1116
KNAUERT, MELISSA P. ET AL.: "Triplex forming oligonucleotides: sequence- specific tools for gene targeting", HUMAN MOLECULAR GENETICS, vol. 10, no. 20, 2001, pages 2243 - 2251
MACRIS, MARGARET A. ET AL.: "Transcription dependence of chromosome gene targeting by triplex-forming oligonucleotides", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 5, 31 January 2003 (2003-01-31), pages 3357 - 3362
SIMON, PHILIPPE ET AL.: "Targeting DNA with triplex-forming oligonucleotides to modify gene sequence", BIOCHIMIE, vol. 90, no. ISSUE, 2008, pages 1109 - 1116
KNAUERT, MELISSA P. ET AL.: "Triplex forming oligonucleotides: sequence- specific tools for gene targeting", HUMAN MOLECULAR GENETICS, vol. 10, no. 20, 2001, pages 2243 - 2251
Attorney, Agent or Firm:
KAUR, Sushil (D6, Sunwaypj,51A, Jalan SS9A/19,,Section 51A, Petaling Jaya, Selangor, MY)
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