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Title:
CIRCULATING TUMOR CELL CAPTURE ON A MICROFLUIDIC CHIP INCORPORATING BOTH AFFINITY AND SIZE
Document Type and Number:
WIPO Patent Application WO/2012/094642
Kind Code:
A3
Abstract:
The invention encompasses methods and devices for diagnosing, theranosing, or prognosing a condition in a patient by enriching a sample in rare cells or other particles. The devices can be a microfluidic device comprising an array of obstacles and one or more binding moieties. The devices and methods can allow for enrichment of cells based on size and affinity, recovery of cells or other particles in locations on the microfluidic device, release of cells or other particles from the microfluidic device, flow of sample through the microfluidic device, and retention of rare cells or other particles from a sample obtained from a patient having a condition.

Inventors:
SKELLEY ALISON (US)
SMIRNOV DENIS (US)
DONG YI (US)
MERDEK KEITH D (US)
SPROTT KAM (US)
CARNEY WALTER (US)
JIANG CHUNSHENG (US)
HUANG RICHARD (US)
LUPASCU IOANA (US)
Application Number:
PCT/US2012/020555
Publication Date:
September 13, 2012
Filing Date:
January 06, 2012
Export Citation:
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Assignee:
ON Q ITY (US)
SKELLEY ALISON (US)
SMIRNOV DENIS (US)
DONG YI (US)
MERDEK KEITH D (US)
SPROTT KAM (US)
CARNEY WALTER (US)
JIANG CHUNSHENG (US)
HUANG RICHARD (US)
LUPASCU IOANA (US)
International Classes:
B01D61/26
Foreign References:
US20100233694A12010-09-16
US20100326914A12010-12-30
US20060134599A12006-06-22
US7007710B22006-03-07
US20070264675A12007-11-15
US20060138079A12006-06-29
Other References:
PRA ET AL.: "Topographic structures and chromatographic supports in microfluidic separation devices.", SCIENCEDIRECT., 11 October 2007 (2007-10-11), Retrieved from the Internet
Attorney, Agent or Firm:
MCANDREW, Christopher William et al. (650 Page Mill RoadPalo Alto, CA, US)
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