Title:
CIS-2,6-DIAZABICYCLO[3.3.0]OCTANE DERIVATIVES AND THEIR MEDICINAL USE
Document Type and Number:
WIPO Patent Application WO/1989/012048
Kind Code:
A1
Abstract:
The invention relates to cis-2,6-diazabicyclo[3.3.0]octane derivatives represented by general formula (I), a peptic ulcer-treating agent containing same as active ingredient, and intermediates (II) and (III) for producing the compounds. In said formula X represents oxygen, sulfur, -NH- or -N< X1 represents alkylene or alkenylene optionally forming a ring together with -N< when X represents -N< Y represents alkylene; Y1 represents hydrogen, alkyl or alkenyl, said alkyl optionally forming substituted or unsubstituted cycloalkyl together with Y2; Y2 represents hydrogen, substituted or unsubstituted alkyl, alkenyl, alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl or heterocyclic ring; A represents hydrogen or hydroxyl optionally having a protective group; R, R1 and R2 each represents hydrogen or alkyl; R3 represents hydrogen, a protective group of nitrogen or alpha; R4 represents hydrogen or a protective group of nitrogen; and Z and W each represents oxygen or sulfur.
Inventors:
ARITA MASAFUMI (JP)
ADACHI KUNITOMO (JP)
SAITOH TADAMASA (JP)
FUKUMASU YOSHITAKA (JP)
HAGA KEIICHIRO (JP)
ADACHI KUNITOMO (JP)
SAITOH TADAMASA (JP)
FUKUMASU YOSHITAKA (JP)
HAGA KEIICHIRO (JP)
Application Number:
PCT/JP1989/000536
Publication Date:
December 14, 1989
Filing Date:
May 29, 1989
Export Citation:
Assignee:
YOSHITOMI PHARMACEUTICAL (JP)
International Classes:
A61K31/40; A61P1/04; A61P7/02; A61P9/00; A61P25/28; C07D487/04; (IPC1-7): C07D487/04; A61K31/40
Other References:
CHEMICAL ABSTRACTS, Vol. 106, No. 14, see Abstract No. 103815f; & DE,A,3525109 (BAYER A. - G.), 15 January 1987.
CHEMICAL ABSTRACTS, Vol. 105, No. 21, see Abstract No. 190991f; & CHEM. LETT., No. 12, 1809-12 (1985).
CHEMICAL ABSTRACTS, Vol. 84, No. 7, see Abstract No. 43998h; & CHEM. BER., Vol. 108, No. 10, 3247-55 (1975).
CHEMICAL ABSTRACTS, Vol. 84, No. 7, see Abstract No. 43899b; & CHEM. BER., Vol. 108, No. 10, 3256-61 (1975).
CHEMICAL ABSTRACTS, Vol. 105, No. 21, see Abstract No. 190991f; & CHEM. LETT., No. 12, 1809-12 (1985).
CHEMICAL ABSTRACTS, Vol. 84, No. 7, see Abstract No. 43998h; & CHEM. BER., Vol. 108, No. 10, 3247-55 (1975).
CHEMICAL ABSTRACTS, Vol. 84, No. 7, see Abstract No. 43899b; & CHEM. BER., Vol. 108, No. 10, 3256-61 (1975).
Download PDF: