Title:
CLASS OF COMPOUNDS FOR INCREASING SENSITIVITY OF PCA DRUG-RESISTANT CELLS TO ANTAGONIST AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/248767
Kind Code:
A1
Abstract:
Disclosed are a class of compounds for increasing the sensitivity of PCa drug-resistant cells to an antagonist and the use thereof. The structural formula of the compounds is formula I. After enzalutamide and such compounds are co-cultured, cell viability is significantly affected, indicating that these compounds increase the sensitivity of prostate cancer drug-resistant cells to enzalutamide. Therefore, such compounds can be applied to the preparation of a drug for increasing the sensitivity of the prostate cancer drug-resistant cells to an androgen receptor antagonist such as enzalutamide.
Inventors:
GAO WEIQIANG (CN)
ZHU HE (CN)
CHEN XIAOQI (CN)
ZHU HE (CN)
CHEN XIAOQI (CN)
Application Number:
PCT/CN2020/122634
Publication Date:
December 16, 2021
Filing Date:
October 22, 2020
Export Citation:
Assignee:
LEADINGEN BIOTECH INC (CN)
International Classes:
A61K31/436; C07D471/04; A61K31/4365; A61K31/4375; A61P15/00; A61P35/00; C07D491/052; C07D495/04
Domestic Patent References:
| WO2018237326A1 | 2018-12-27 |
Foreign References:
| CN108245511A | 2018-07-06 |
Other References:
DATABASE CAPLUS 30 October 2007 (2007-10-30), AMERICAN CHEMICAL SOCIETY: "FIL REG for CN111961046/PN 2020:2430358", XP009532815, retrieved from STN
Attorney, Agent or Firm:
DUAN&DUAN LAW FIRM (CN)
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