Title:
CLASSIFICATION UNIT COMPONENT COMPUTING METHOD FOR SEQUENCING DATA
Document Type and Number:
WIPO Patent Application WO/2021/227329
Kind Code:
A1
Abstract:
A classification unit component computing method for sequencing data. The method measures the situation of misalignment of classification units in a sequence alignment result on the basis of indexes of the "frequencies of secondary classification units of sequencing read sequences" and a computing framework thereof, and can effectively remove a false positive result in the classification unit component computation, thereby improving the specificity and accuracy of the component computation. The method also implements regression of the misaligned sequences to a real component result by means of a strategy of recounting after the abnormal classification units are removed, thus effectively correcting the quantitative result of the abundance of the classification units.
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Inventors:
LIANG CHEN (CN)
HU LONG (CN)
WU SUSHENG (CN)
YANG FAN (CN)
XIAO NIANQING (CN)
REN YONG (CN)
HU LONG (CN)
WU SUSHENG (CN)
YANG FAN (CN)
XIAO NIANQING (CN)
REN YONG (CN)
Application Number:
PCT/CN2020/116645
Publication Date:
November 18, 2021
Filing Date:
September 22, 2020
Export Citation:
Assignee:
JIANGSU SIMCERE DIAGNOSTICS CO LTD (CN)
JIANGSU SIMCERE MEDICAL EQUIPMENT CO LTD (CN)
BEIJING SIMCERE MEDICAL LABORATORY CO LTD (CN)
JIANGSU SIMCERE MEDICAL EQUIPMENT CO LTD (CN)
BEIJING SIMCERE MEDICAL LABORATORY CO LTD (CN)
International Classes:
G16B30/10
Domestic Patent References:
| WO2012170436A1 | 2012-12-13 |
Foreign References:
| CN111599413A | 2020-08-28 | |||
| CN106636433A | 2017-05-10 | |||
| CN108280352A | 2018-07-13 | |||
| CN110349630A | 2019-10-18 |
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