Title:
CLINDAMYCIN PHOSPHATE PURIFICATION METHOD
Document Type and Number:
WIPO Patent Application WO/2021/098847
Kind Code:
A1
Abstract:
A clindamycin phosphate purification method, comprising: dissolving surfactant trioctylmethylammonium chloride (TOMAC) in organic solvent ethyl acetate to make a reverse micelle extraction system; dissolving surfactant actyl-β-D-glucopyranoside (OGP) and clindamycin phosphate crude product in purified water as an aqueous phase; mixing the reverse micelle extraction system and the aqueous phase, performing extraction, and leaving to stand for phase separation to obtain a reverse micelle extraction phase containing clindamycin phosphate; and then adding inorganic salt to make the clindamycin phosphate crystallise and precipitate from the reverse micelle extraction phase, and separating. The present invention is conducive to increasing the purity of the product, and avoids the use of flammable and explosive organic solvents, reduces sewage discharge, thereby decreasing the pressure of environmental protection, and reduces production costs whilst also reducing safety risks in the production environment.
Inventors:
GUO JIA (CN)
YU RONG (CN)
LIU PENG (CN)
ZHANG HANGZHOU (CN)
ZHANG XIAOQIANG (CN)
YU RONG (CN)
LIU PENG (CN)
ZHANG HANGZHOU (CN)
ZHANG XIAOQIANG (CN)
Application Number:
PCT/CN2020/130604
Publication Date:
May 27, 2021
Filing Date:
November 20, 2020
Export Citation:
Assignee:
NINGXIA TAIYICIN BIOTECH CO LTD (CN)
International Classes:
C07H1/06; C07H15/16
Foreign References:
| CN111004293A | 2020-04-14 | |||
| CN103772454A | 2014-05-07 | |||
| CN107880083A | 2018-04-06 | |||
| CN101928307A | 2010-12-29 | |||
| IN184009B | 2000-06-03 |
Other References:
LI XIALAN, WENG LIANJIN: "Technology of Reversed Micelles Extraction and its Application in Antibiotics Separation", ZHONGGUO KANGSHENGSU ZAZHI/ CHINESE JOURNAL OF ANTIBIOTICS., SICHUAN., CN, vol. 28, no. 9, 1 September 2003 (2003-09-01), CN, pages 576 - 578, XP055814070, ISSN: 1001-8689
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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