Title:
CLINICAL APPLICATION OF CELLS AS VECTORS FOR GENE THERAPY
Document Type and Number:
WIPO Patent Application WO/2023/284380
Kind Code:
A1
Abstract:
Provided is a clinical application of cells as vectors for gene therapy. Exosomes are used as primary vectors to load RNAs required for treatment, autologous or allogeneic mature somatic cells having high clinical safety or precursor cells of mature somatic cells having low immunogenicity are used as secondary vectors to load specific exosomes, and the cells are injected into a body for treatment. According to the cell therapy method, cells can be enriched around a disease, continuously generate and release exosomes, and the exosomes enter target cells by means of a specific targeting function, so as to achieve the purpose of introducing therapeutic genes to achieve treatment. The cell therapy method has good clinical application prospects due to its safety and effectiveness.
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Inventors:
GU YUCHUN (CN)
WU LIDA (CN)
WU LIDA (CN)
Application Number:
PCT/CN2022/091281
Publication Date:
January 19, 2023
Filing Date:
May 06, 2022
Export Citation:
Assignee:
ALLIFE MEDICAL SCIENCE AND TECH CO LTD (CN)
International Classes:
A61K47/69; A61K47/64; A61K47/65; C07K19/00; C12N15/85
Domestic Patent References:
| WO2014049125A1 | 2014-04-03 | |||
| WO2020225392A1 | 2020-11-12 |
Foreign References:
| CN109689109A | 2019-04-26 | |||
| CN111629760A | 2020-09-04 | |||
| US20150093433A1 | 2015-04-02 | |||
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| US20040121323A1 | 2004-06-24 | |||
| CN113527519A | 2021-10-22 | |||
| CN113528526A | 2021-10-22 |
Other References:
HUANG LIN, GU NING, ZHANG XIAN-EN, WANG DIAN-BING: "Light-Inducible Exosome-Based Vehicle for Endogenous RNA Loading and Delivery to Leukemia Cells", ADVANCED FUNCTIONAL MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 29, no. 9, 1 February 2019 (2019-02-01), DE , pages 1807189, XP055913313, ISSN: 1616-301X, DOI: 10.1002/adfm.201807189
STATELLO LUISA, MAUGERI MARCO, GARRE ELENA, NAWAZ MUHAMMAD, WAHLGREN JESSICA, PAPADIMITRIOU ALEXANDROS, LUNDQVIST CHRISTINA, LINDF: "Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes", PLOS ONE, vol. 13, no. 4, pages e0195969, XP093023748, DOI: 10.1371/journal.pone.0195969
SHULAN LIU, YILIN ZHOU, LILI ZHOU, MANSHU ZOU, XINHUA XIA: "Research Progress on Exosomes as siRNA Delivery Carriers", CHINESE JOURNAL OF MODERN APPLIED PHARMACY, CHINESE PHARMACEUTICAL ASSOCIATION, CN, vol. 38, no. 7, 30 April 2021 (2021-04-30), CN , pages 38 - 880, XP093023917, ISSN: 1007-7693, DOI: 10.13748/j.cnki.issn1007-7693.2021.07.020
STATELLO LUISA, MAUGERI MARCO, GARRE ELENA, NAWAZ MUHAMMAD, WAHLGREN JESSICA, PAPADIMITRIOU ALEXANDROS, LUNDQVIST CHRISTINA, LINDF: "Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes", PLOS ONE, vol. 13, no. 4, pages e0195969, XP093023748, DOI: 10.1371/journal.pone.0195969
SHULAN LIU, YILIN ZHOU, LILI ZHOU, MANSHU ZOU, XINHUA XIA: "Research Progress on Exosomes as siRNA Delivery Carriers", CHINESE JOURNAL OF MODERN APPLIED PHARMACY, CHINESE PHARMACEUTICAL ASSOCIATION, CN, vol. 38, no. 7, 30 April 2021 (2021-04-30), CN , pages 38 - 880, XP093023917, ISSN: 1007-7693, DOI: 10.13748/j.cnki.issn1007-7693.2021.07.020
Attorney, Agent or Firm:
BEIJING PREINTELL IP CO., LTD (CN)
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