Title:
CLONING AND EXPRESSION OF HUMAN ISLET GLUTAMIC ACID DECARBOXYLASE AUTOANTIGEN
Document Type and Number:
WIPO Patent Application WO1992020811
Kind Code:
A3
Abstract:
Human pancreatic islet cell glutamic acid decarboxylase (GAD), an autoantigen involved in the development of insulin-dependent diabetes mellitus (IDDM), has been cloned, sequenced and expressed by recombinant means. Recombinant human islet cell GAD polypeptides and antibodies specific to the GAD polypeptides can be used in methods of diagnosis and treatment, including use in immunoadsorptive therapy and the induction of immune tolerance.
Inventors:
LERNMARK AKE (US)
KARLSEN ALLEN E (US)
GRUBIN CATHERINE E (US)
HAGOPIAN WILLIAM (US)
O'HARA PATRICK J (US)
FOSTER DONALD C (US)
KARLSEN ALLEN E (US)
GRUBIN CATHERINE E (US)
HAGOPIAN WILLIAM (US)
O'HARA PATRICK J (US)
FOSTER DONALD C (US)
Application Number:
PCT/US1992/004079
Publication Date:
January 21, 1993
Filing Date:
May 14, 1992
Export Citation:
Assignee:
ZYMOGENETICS INC (US)
UNIV WASHINGTON (US)
UNIV WASHINGTON (US)
International Classes:
A61P37/00; C07K16/40; C12N1/21; C12N9/04; C12N9/88; C12N15/09; G01N33/53; A61K38/00; G01N33/573; A61K38/095; C12R1/19; (IPC1-7): C12P19/34; C12N15/00; C12N5/00; C12N7/00; C12N1/16; C12Q1/68; C07K3/00; C07H15/12; A01N37/18
Domestic Patent References:
| WO1990007117A1 | 1990-06-28 | |||
| WO1992005446A1 | 1992-04-02 | |||
| WO1992003733A1 | 1992-03-05 | |||
| WO1992004632A1 | 1992-03-19 | |||
| WO1992014485A1 | 1992-09-03 |
Other References:
NATURE vol. 347, no. 6289, 13 September 1990, MACMILLAN JOURNALS LTD., LONDON, UK; pages 151 - 156 S. BAEKKESKOV ET AL. 'Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase'
J. CLIN. INVESTIGATION vol. 79, no. 3, March 1987, ASCI, ROCKEFELLER UNIV. PRESS, US; pages 926 - 934 S. BAEKKESKOV ET AL. 'Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes'
CLINICAL RESEARCH vol. 39, no. 2, 6 May 1991, THOROFARE, N.J.,US; page 173A A.E. KARLSEN ET AL. 'Immune recognition and gene expression of islet glutamic acid decarboxylase'
Joint meeting of the association of american physicians, the american society for clinical investigation, and the american federation for clinical research, seattle, washington, USA, May 3-6, 1991 abstract
PROC. NATL. ACAD SCI. vol. 88, no. 19, 1 October 1991, NATL. ACAD SCI., WASHINGTON, DC, US; pages 8337 - 8341 A.E.KARLSEN 'Cloning and promary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10'
PROC. NATL. ACAD SCI. vol. 89, no. 6, 15 March 1992, NATL. ACAD SCI., WASHINGTON, DC, US; pages 2115 - 2119 D.-F. BU ET AL. 'Two human glutamate decarboxylases, 65kDa GAD and 67-kDa GAD, are each encoded by a single gene'
J. CLIN. INVESTIGATION vol. 79, no. 3, March 1987, ASCI, ROCKEFELLER UNIV. PRESS, US; pages 926 - 934 S. BAEKKESKOV ET AL. 'Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes'
CLINICAL RESEARCH vol. 39, no. 2, 6 May 1991, THOROFARE, N.J.,US; page 173A A.E. KARLSEN ET AL. 'Immune recognition and gene expression of islet glutamic acid decarboxylase'
Joint meeting of the association of american physicians, the american society for clinical investigation, and the american federation for clinical research, seattle, washington, USA, May 3-6, 1991 abstract
PROC. NATL. ACAD SCI. vol. 88, no. 19, 1 October 1991, NATL. ACAD SCI., WASHINGTON, DC, US; pages 8337 - 8341 A.E.KARLSEN 'Cloning and promary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10'
PROC. NATL. ACAD SCI. vol. 89, no. 6, 15 March 1992, NATL. ACAD SCI., WASHINGTON, DC, US; pages 2115 - 2119 D.-F. BU ET AL. 'Two human glutamate decarboxylases, 65kDa GAD and 67-kDa GAD, are each encoded by a single gene'
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