Title:
CO-CRYSTAL OF HINOKITIOL AND TERT-BUTYLHYDROQUINONE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/247696
Kind Code:
A1
Abstract:
The present invention relates to a co-crystal of hinokitiol and tert-butylhydroquinone, a preparation method therefor, and a use thereof. The co-crystal of hinokitiol and tert-butylhydroquinone is triclinic, the space group is space group P-1, and unit cell parameters are a=6.945, b=9.401, c=16.268, α=74.924°, β=80.195°, and γ=72.024°. Compared with hinokitiol itself, the melting point of the co-crystal of hinokitiol and tert-butylhydroquinone of the present invention is significantly increased, the volatility at high temperature is reduced, long-term storage stability is increased, and light stability is significantly improved.
Inventors:
MEI XUEFENG (CN)
MA XIAOYU (CN)
ZHU BINGQING (CN)
WANG JIANRONG (CN)
MA XIAOYU (CN)
ZHU BINGQING (CN)
WANG JIANRONG (CN)
Application Number:
PCT/CN2022/093478
Publication Date:
December 01, 2022
Filing Date:
May 18, 2022
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07C49/717; C07C37/70; C07C39/11; C07C45/81
Foreign References:
| CN113307730A | 2021-08-27 | |||
| CN107661505A | 2018-02-06 | |||
| CN111620766A | 2020-09-04 | |||
| CN100999451A | 2007-07-18 | |||
| CN101396021A | 2009-04-01 | |||
| CN108586215A | 2018-09-28 | |||
| CN112516116A | 2021-03-19 | |||
| CN103755561A | 2014-04-30 |
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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